Phase 4
Completed N=20
Intraarticular Antibiotic in TKA
Antibotics in Cementless Knees
Source: ClinicalTrials.gov NCT04297631 ↗
Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Oct 2021
Primary outcomePrimary: Concentration of Antibiotics in Cementless Knees Post op — 1702.5; 582.5; 56.1; 1943 micrograms per milliliter
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The purpose of the study is to determine the intra-articular concentration of vancomycin and tobramycin after administration of vancomycin and tobramycin powder in primary cementless total knee arthroplasty and determine the serum concentrations of these antibiotics postoperatively.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Concentration of Antibiotics in Cementless Knees Post op |
1702.5; 582.5; 56.1; 1943; 345; 8.7 | — |
| SECONDARY Serum Concentrations of Vancomycin and Tobramycin at 1, 4, and 24 Hours. |
2.3; 4.6; 3.1; 6.3; 8; .8 | — |
Eligibility Criteria
Inclusion Criteria
- Age over 18
- Total knee arthroplasty for primary osteoarthritis. Primary diagnosis of knee osteoarthritis
Exclusion Criteria
- Diminished mental capacity
- Vancomycin allergy
- Tobramycin allergy
- Chronic kidney disease stage III and stage IV
Data sourced from ClinicalTrials.gov (NCT04297631). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.