N/A
N=90
Neural Mechanisms of Successful Intervention in Children With Dyslexia
Dyslexia, Developmental
Bottom Line
View on ClinicalTrials.gov: NCT04323488 ↗Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcome: Primary: White Matter Plasticity - Left Arcuate Tract — 0.837; 0.838; 0.842; 0.844 mm^2/s — p=0.925
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Lindamood-Bell Seeing Stars (Behavioral)
- Age
- Pediatric · 8+ yrs
- Sex
- All
- Sponsor
- Stanford University
- Primary completion
- Sep 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY White Matter Plasticity - Left Arcuate Tract |
0.837; 0.838; 0.842; 0.844; 0.839; 0.830 | 0.925 |
| PRIMARY White Matter Plasticity - Inferior Longitudinal Tract |
0.963; 0.957; 0.963; 0.956; 0.957; 0.952 | 0.524 |
| PRIMARY Visual Word Form Area (VWFA) Size |
142.00; 302.74; 146.69; 282.40; 375.53; 337.20 | 0.60 |
| PRIMARY Woodcock-Johnson Basic Reading Skills (WJ BRS) Assessment Battery |
80.75; 96.85; 88.33; 96.02; 89.95; 95.10 | < 0.001 sig |
Summary
Dyslexia, an impairment in accurate or fluent word recognition, is the most common learning disability affecting roughly ten percent of children. This proposal capitalizes on cutting edge neuroimaging methods, in combination with reading education programs, to generate a new understanding of how successful reading education shapes the development of the brain circuits that support skilled reading. A deeper understanding of the mechanisms of successful remediation of dyslexia, and individual differences in learning, will pave the way for personalized approaches to dyslexia treatment.
Eligibility Criteria
Inclusion Criteria
- Reading difficulties defined as low scores on standardized measures of reading skills
Exclusion Criteria
- no major contraindication for MRI (braces, metal implants, pacemakers, vascular stents, or metallic ear tubes).
- Because the study involves measurements of reading and language ability, new recruits will be native English speakers.
- Subjects have no history of neurological disorder, significant psychiatric problems
- exclude claustrophobic subjects since an MRI might be uncomfortable for them.
Data sourced from ClinicalTrials.gov (NCT04323488). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.