N/A
Completed N=129
Optical Coherence Tomography Angiography Evaluation of Ocular Changes in Patients With Carotid Artery Stenosis
Source: ClinicalTrials.gov NCT04326842 ↗Enrolled (actual)
129
Serious AEs
1.6%
Results posted
Oct 2020
Primary outcomePrimary: Radical Peripapillary Capillaries Vessel Density — 55.95; 57.24 percentage of vessel
Summary
This study aims to evaluate ocular changes in patients with carotid artery stenosis by optical coherence tomography angiography before and after carotid artery revascularization procedure.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Radical Peripapillary Capillaries Vessel Density |
55.95; 57.24 | — |
| PRIMARY Superficial Vascular Complexes Vessel Density |
48.65; 52.22 | — |
| PRIMARY Deep Vascular Complexes Vessel Density |
49.65; 57.50 | — |
| PRIMARY Choriocapillaris Vessel Density |
67.41; 68.74 | — |
| SECONDARY Change of Difference of Mean Transit Time(dMTT) |
-0.22 | — |
| SECONDARY Change of the Ratio of Cerebral Blood Flow(rCBF) |
0.19 | — |
| SECONDARY Changes of Retinal Nerve Fiber Layer |
2.50 | — |
| SECONDARY Changes of Deep Vascular Complexes Vessel Density |
4.00 | — |
| SECONDARY Changes of Radical Peripapillary Capillaries Vessel Density |
1.55 | — |
| SECONDARY Changes of Superficial Vascular Complexes Vessel Density |
1.70 | — |
Eligibility Criteria
Inclusion Criteria
- Clinical diagnosis of carotid artery stenosis
- Age-gender-race-matched controls
Exclusion Criteria
- age 21 mmHg
- VA >logMAR 1.0
- spherical equivalent (SE) between >1.00 or < -6.00 D
- other serious eye diseases which may affect OCTA results including diabetic retinopathy, hypertensive retinopathy, retinal vascular occlusion, age-related macular degeneration, and uveitis
- major intraocular surgery performed in the past 6 months or a history of laser photocoagulation or intravitreal injection
- glaucoma or first-degree relatives with a history of glaucoma; and
- any disease that might cause poor scan quality (image quality <6).
Data sourced from ClinicalTrials.gov (NCT04326842). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.