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Phase 3 Completed N=366 Randomized Quadruple-blind Treatment

Motion Syros: A Study to Investigate the Efficacy of Tradipitant in Subjects Affected by Motion Sickness

Motion Sickness
Source: ClinicalTrials.gov NCT04327661 ↗
Enrolled (actual)
366
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Prevention of Vomiting Measured by Vomiting Assessment (VA) — 22; 24; 54 Participants
◆ Published Evidence
Emerging
8citations · ~8 / year
Motion Syros: tradipitant effective in the treatment of motion sickness; a multicenter, randomized, double-blind, placebo-controlled study.
Frontiers in neurology · 2025 · Open access · Likely link

Summary

A multi-center, randomized, double-blind, placebo-controlled study to investigate the efficacy of tradipitant in subjects affected by motion sickness during travel

Linked Publications (2)

  • Motion Syros: tradipitant effective in the treatment of motion sickness; a multicenter, randomized, double-blind, placebo-controlled study.
    Frontiers in neurology · 2025 · 8 citations · Open access · Likely link
  • Tradipitant: A Novel Neurokinin-1 Receptor Antagonist for Motion Sickness.
    American journal of therapeutics · 2026 · 0 citations · Likely link

Outcome Measures

OutcomeResultp-value
PRIMARY
Prevention of Vomiting Measured by Vomiting Assessment (VA)
22; 24; 54

Eligibility Criteria

Inclusion Criteria

  • History of motion sickness
  • Age 18-75

Exclusion Criteria

  • Nausea-inducing disorder other than motion sickness
  • BMI>40
  • History of intolerance and/or hypersensitivity to Neurokinin-1 Receptor antagonists
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04327661) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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