N/A
Completed N=139
Cigarette Smoking Among Young Adults
Cigarette Smoking · Smoking Behaviors
Source: ClinicalTrials.gov NCT04340947 ↗
Enrolled (actual)
139
Serious AEs
0.0%
Results posted
Aug 2025
Primary outcomePrimary: Puff Topography — 1108; 1045.2; 1084.6 mL
Summary
This study will examine perceptions and smoking behavior of menthol and non-menthol very low nicotine cigarettes in young adult smokers. The aims are to examine perceptions and smoking behavior in the laboratory and in the natural environment. A separate sub-sample of men and women who identify as LGBTQ2S+ will also be recruited.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Puff Topography |
1108; 1045.2; 1084.6 | — |
| PRIMARY Ratings of Psychological Reward |
3.1; 2.9; 2.3 | — |
| PRIMARY Hypothetical Purchasing of Non-Menthol Very Low Nicotine Cigarettes (VLNCs) |
20.40; 6.11; 14.44; 3.66; 10.17; 3.37 | — |
| SECONDARY Exhaled CO Boost |
4.08; 3.72; 3.9; 9.17; 7.65; 6.79 | — |
Eligibility Criteria
Inclusion Criteria
- Ages18 to 34;
- Smoke cigarettes "somedays" or "everyday" for at least the past 3-months;
- A strong preference for menthol cigarettes (i.e., smoke menthol >80% of the time); and
- Ability to read English at an 8th grade level or higher;
- No immediate plans to quit smoking.
Exclusion Criteria
- Current use of nicotine replacement therapy (NRT);
- Pregnant or planning to become pregnant, or currently breastfeeding;
- Past or current self-reported clinically significant heart disease or hypertension, or other smoking-related disease (by history) that preclude successful study completion;
- Serious psychiatric disorder;
- Inability to abstain from nicotine/tobacco products;
- Strong preference for non-menthol cigarettes (smoke non-menthol > 80% of the time)
Data sourced from ClinicalTrials.gov (NCT04340947). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.