Phase 3
Completed N=25
The Effect of empagliFlozin on Platelet Function profilEs in diabetiC patienTs - The EFFECT Study.
Platelet Dysfunction Due to Drugs
Source: ClinicalTrials.gov NCT04342819 ↗
Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Sep 2024
Primary outcomePrimary: P2Y12 Reaction Units — 187.35 P2Y12 Reaction Units
◆ Published Evidence
Emerging
13citations · ~3 / year
The Effect of Empagliflozin on Platelet Function Profiles in Patients with Stable Coronary Artery Disease in Trinidad: The EFFECT Pilot Study.
Summary
The mechanistic effects of empagliflozin on platelet function profiles have not yet been ascertained.
Linked Publications
-
The Effect of Empagliflozin on Platelet Function Profiles in Patients with Stable Coronary Artery Disease in Trinidad: The EFFECT Pilot Study.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY P2Y12 Reaction Units |
187.35 | — |
Eligibility Criteria
Inclusion Criteria
- between 18 and 74 years of age,
- have stable coronary artery disease and diabetes mellitus, already on DAPT with aspirin and clopidogrel for at least 6 months,
Exclusion Criteria
- presence of active internal bleeding or history of bleeding diathesis or clinical findings associated with an increased risk of bleeding,
- history of ischemic or hemorrhagic stroke, transient ischemic attack, intracranial neoplasm, arteriovenous malformation, or aneurysm,
- history of clinical and/or hemodynamic instability,
- within 1 month of placement of a bare metal stent,
- within 30 days of coronary artery bypass graft surgery or PCI without a stent placed,
- planned coronary revascularization,
- treatment with fibrin-specific fibrinolytic therapy 1.5,
- body weight 75 years,
- hemoglobin 2 mg/dL,
- hepatic enzymes >2.5 times the upper limit of normal,
- pregnancy and/or lactation.
Data sourced from ClinicalTrials.gov (NCT04342819) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.