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Phase 4 Completed N=166 Randomized Treatment

Argon Plasma Coagulation vs Hemoclipping for Bleeding Peptic Ulcers

Bleeding Peptic Ulcer
Source: ClinicalTrials.gov NCT04366583 ↗
Enrolled (actual)
166
Serious AEs
1.2%
Results posted
Oct 2020
Primary outcomePrimary: Number of Participants With Rebleeding — 3; 4 Participants
◆ Published Evidence
No publication linked

No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.

Summary

Endoscopic treatment is recommended for initial hemostasis in nonvariceal upper gastrointestinal bleeding. However, the additional hemostatic efficacy of argon plasma coagulation (APC) has not been widely investigated. We designed a randomized trial comparing APC plus injection therapy vs hemoclipping plus injection therapy for peptic ulcer bleeding.

Outcome Measures

OutcomeResultp-value
PRIMARY
Number of Participants With Rebleeding
3; 4
SECONDARY
Mortality
0; 1
SECONDARY
Surgery or Arterial Embolization
0; 1

Eligibility Criteria

Inclusion Criteria

. high-risk peptic ulcer bleeding. High-risk bleeding ulcers were defined as participants with stigmata of a bleeding visible vessels (eg, spurting, oozing), a non-bleeding visible vessels (NBVV) or adherent clot.4 A NBVV at endoscopy was defined as a raised red, red-blue or pale hemispheric vessel protruding from the ulcer bed, without active bleeding. An adherent clot was defined as an overlying blood clot that was resistant to vigorous irrigation.

Exclusion Criteria

  • the presence of another possible bleeding site (eg, gastroesophageal varix, gastric cancer, reflux esophagitis)
  • coexistence of actively severe ill diseases (eg, septic shock, stroke, myocardial infarction, surgical abdomen)
  • treatment with an anticoagulant (eg, warfarin)
  • pregnancy
  • the presence of operated stomach
  • refusal to participate in the study
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04366583). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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