N/A
Completed N=208
Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms
Osteo Arthritis Knee
Source: ClinicalTrials.gov NCT04375072 ↗
Enrolled (actual)
208
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcomePrimary: Change in Numeric Rating Score (NRS) of Pain — -19.41; -7.16; -16.78; -6.20 units on a scale
Summary
This clinical trial aims to evaluate whether a 2 week regimen of transcranial direct current stimulation (tDCS) paired with mindfulness-based meditation (MBM) can improve pain modulation, reduce clinical pain, and alleviate osteoarthritis (OA)-related symptoms in patients with knee OA.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Numeric Rating Score (NRS) of Pain |
-19.41; -7.16; -16.78; -6.20 | — |
| SECONDARY Change in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). |
-6.98; -7.90; -8.08; -4.50 | — |
Eligibility Criteria
Inclusion Criteria
- have symptomatic knee OA based on American College of Rheumatology clinical criteria
- have had knee OA pain in the past 3 months with an average of at least 30 on a 0-100 NRS for pain,
- can speak and read English
- have no plan to change medication regimens for pain throughout the trial
Exclusion Criteria
- history of brain surgery, brain tumor, seizure, stroke, or intracranial metal implantation
- systemic rheumatic disorders, including rheumatoid arthritis,systemic lupus erythematosus, and fibromyalgia
- alcohol/substance abuse
- diminished cognitive function that would interfere with understanding study procedures (i.e., Mini-Mental Status Exam score ≤ 23)
- pregnancy or lactation
- prosthetic knee replacement or non-arthroscopic surgery to the affected knee
- hospitalization within the preceding year for psychiatric illness
- no access to a device that can be used for secure videoconferencing for real-time remote supervision.
Data sourced from ClinicalTrials.gov (NCT04375072). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.