N/A
Completed N=25
Individualized Closed Loop TMS for Working Memory Enhancement
Memory
Source: ClinicalTrials.gov NCT04402294 ↗
Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: Reaction Time Changes During N-Back Task in Responses to Different TMS Frequencies — 0.5853; 0.5978; 0.6012 Seconds — p=0.50
Summary
The study is investigating working memory brain states by using transcranial magnetic stimulation (TMS) in combination with functional magnetic resonance imaging (fMRI). The study uses a novel, individualized targeting approach for TMS based on each subject's individual multi-modal fMRI data. The individualized target will be stimulated in a TMS/ fMRI imaging session to investigate working memory states and optimal stimulation frequencies.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Reaction Time Changes During N-Back Task in Responses to Different TMS Frequencies |
0.5853; 0.5978; 0.6012 | 0.50 |
| PRIMARY Accuracy Changes During N-Back Task in Responses to Different TMS Frequencies |
91.27; 90.71; 90.54 | 0.975 |
| PRIMARY Reaction Time Changes in the Delayed Matching to Sample Task Following Optimal vs. Suboptimal rTMS Stimulation |
2.0173; 1.7568; 1.9316; 2.0608; 1.9118; 1.9139 | 0.097 |
| PRIMARY Accuracy Changes in the Delayed Matching to Sample Task Following Optimal vs. Suboptimal rTMS Stimulation |
84.2667; 88.1011; 83.9079; 86.0638; 87.8524; 84.3748 | 0.644 |
| SECONDARY Reaction Time Changes in the Reaction Time Index Task Following Optimal vs. Suboptimal rTMS Stimulation |
0.716; 0.722; 0.687; 0.736; 0.713; 0.693 | 0.439 |
| SECONDARY Movement Time Changes in the Reaction Time Index Task Following Optimal vs. Suboptimal rTMS Stimulation |
0.411; 0.417; 0.381; 0.411; 0.406; 0.395 | 0.563 |
Eligibility Criteria
Inclusion Criteria
1)18-60 years old 2) Right handed 3) No psychiatric history as diagnosed by the SCID-V 4) Normal cognition 5) Capacity to give informed consent and follow study procedures 6) Sufficient command of English language to understand and respond to written as well as verbal instructions
Exclusion Criteria
- History of neurological disorder or traumatic brain injury (other than mild)
- Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- Unable to receive TMS
- Implanted devices, such as an aneurysm clip or cardiac pacemaker
- History of stroke, epilepsy, or brain scarring
- Recent use of psychoactive medications, as determined by investigators
- Pregnant, nursing, or trying to become pregnant (self-attestation alone)
- Color blindness
- Otherwise determined by investigator to be unfit for study
Data sourced from ClinicalTrials.gov (NCT04402294). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.