Phase 2
Completed N=20
Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients
Source: ClinicalTrials.gov NCT04410159 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcomePrimary: Number of Participants With Early Viral Clearance — 5; 4; 1; 0 Participants
Summary
The purpose of this study is to assess the ability of regular gargling to eliminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the throat and nasopharynx. This 4 arms interventional study compares the effect of gargling using povidone-iodine, essential oils- based, tap water with control (no intervention) among Stage 1 coronavirus disease-2019 (COVID-19) patients.
Findings from this study will provide new insight into the importance of gargling in the treatment and prevention of COVID-19.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Early Viral Clearance |
5; 4; 1; 0 | — |
| SECONDARY Number of Participants With Negative RT-PCR Results |
5; 4; 2; 1 | — |
| SECONDARY Number of Patients That Progress to More Severe Disease |
0; 0; 0; 0 | — |
| SECONDARY Number of Patients With Abnormal Radiological Findings |
0; 0; 0; 0 | — |
| SECONDARY Number of Patients With Abnormal Laboratory Findings |
0; 0; 0; 0 | — |
Eligibility Criteria
Inclusion Criteria
- adult aged 18 years and above
- able to understand instructions
- Stage 1 COVID-19
- < 5 days of illness or diagnosis
Exclusion Criteria
- Less than 18 years old
- Unable to understand instructions
- Stage 2 & 3 COVID-19
- Respiratory symptoms or fever on admission
- Abnormal chest radiograph or computed tomography (CT) findings on admission
Data sourced from ClinicalTrials.gov (NCT04410159). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.