Phase 2 N=20 Randomized Treatment

Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients

COVID-19

Bottom Line

View on ClinicalTrials.gov: NCT04410159 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jul 2020

Primary outcome: Primary: Number of Participants With Early Viral Clearance — 5; 4; 1; 0 Participants

Study Design & Population

Study type: Interventional
Phase: Phase 2
Interventions: Povidone-Iodine (Drug); Essential oils (Drug); Tap water (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Universiti Sains Islam Malaysia
Primary completion: Jun 2020

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants With Early Viral Clearance	5; 4; 1; 0	—
SECONDARY Number of Participants With Negative RT-PCR Results	5; 4; 2; 1	—
SECONDARY Number of Patients That Progress to More Severe Disease	0; 0; 0; 0	—
SECONDARY Number of Patients With Abnormal Radiological Findings	0; 0; 0; 0	—
SECONDARY Number of Patients With Abnormal Laboratory Findings	0; 0; 0; 0	—

Summary

The purpose of this study is to assess the ability of regular gargling to eliminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the throat and nasopharynx. This 4 arms interventional study compares the effect of gargling using povidone-iodine, essential oils- based, tap water with control (no intervention) among Stage 1 coronavirus disease-2019 (COVID-19) patients. Findings from this study will provide new insight into the importance of gargling in the treatment and prevention of COVID-19.

Eligibility Criteria

Inclusion Criteria

adult aged 18 years and above
able to understand instructions
Stage 1 COVID-19
< 5 days of illness or diagnosis

Exclusion Criteria

Less than 18 years old
Unable to understand instructions
Stage 2 & 3 COVID-19
Respiratory symptoms or fever on admission
Abnormal chest radiograph or computed tomography (CT) findings on admission

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04410159). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.