N/A
N=39
cTBS/fMRI Study of Hierarchical Control in the PFC
Transcranial Magnetic Stimulation
Bottom Line
View on ClinicalTrials.gov: NCT04464473 ↗Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: PFC-PPC Effective Connectivity — 0.3646; 0.3756; 0.3425; 0.4519 Hertz — p=0.5736
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- transcranial magnetic stimulation (Device)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Florida State University
- Primary completion
- Apr 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY PFC-PPC Effective Connectivity |
0.3646; 0.3756; 0.3425; 0.4519; 0.466; 0.4004 | 0.5736 |
| PRIMARY PFC-PPC Activation |
0.1132; 0.1155; 0.0992; 0.1519; 0.1619; 0.162 | 0.8152 |
| SECONDARY Temporal Control Performance (Error Rate) |
4.541; 3.826; 4.329; -0.293; -0.942; 0.358 | 0.9504 |
| SECONDARY Contextual Control Performance (Error Rate) |
5.580; 6.950; 5.890; 1.990; 2.960; 2.700 | 0.0266 sig |
| SECONDARY Temporal x Contextual Control Performance (Error Rate) |
-1.810; 0.082; -2.181; 1.270; 1.141; 1.400 | 0.0091 sig |
| SECONDARY Temporal Control Performance (Reaction Time) |
15.700; 11.987; -2.244; -18.172; -16.540; -23.348 | 0.0211 sig |
| SECONDARY Contextual Control Performance (Reaction Time) |
197.700; 185.443; 160.900; 163.774; 146.982; 132.500 | 0.0344 sig |
| SECONDARY Temporal Control x Contextual Control Performance (Reaction Time) |
55.600; 53.162; 53.280; 141.900; 131.227; 125.100 | 0.0189 sig |
Summary
The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.
Eligibility Criteria
Inclusion Criteria
- Between the ages of 18 and 30
- Right-handed
- Native English speaker or fluent by the age of 6
Exclusion Criteria
- History of psychiatric disorders
- History of neurological disorders
- Receiving medications for psychiatric or neurological disorders
- Familial history of epilepsy
- Taking any drugs or medications that are pro-epileptic
- Metal anywhere in the head excluding the mouth
- Tinnitus
- Women who are pregnant
Data sourced from ClinicalTrials.gov (NCT04464473). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.