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N/A Completed N=39 Randomized Single-blind Basic Science

cTBS/fMRI Study of Hierarchical Control in the PFC

Transcranial Magnetic Stimulation
Source: ClinicalTrials.gov NCT04464473 ↗
Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcomePrimary: PFC-PPC Effective Connectivity — 0.3646; 0.3756; 0.3425; 0.4519 Hertz — p=0.5736

Summary

The objective of this study is to examine the effect of transcranial magnetic stimulation (TMS) on the prefrontal cortex and posterior parietal cortex.

Outcome Measures

OutcomeResultp-value
PRIMARY
PFC-PPC Effective Connectivity		 0.3646; 0.3756; 0.3425; 0.4519; 0.466; 0.4004 0.5736
PRIMARY
PFC-PPC Activation		 0.1132; 0.1155; 0.0992; 0.1519; 0.1619; 0.162 0.8152
SECONDARY
Temporal Control Performance (Error Rate)		 4.541; 3.826; 4.329; -0.293; -0.942; 0.358 0.9504
SECONDARY
Contextual Control Performance (Error Rate)		 5.580; 6.950; 5.890; 1.990; 2.960; 2.700 0.0266 sig
SECONDARY
Temporal x Contextual Control Performance (Error Rate)		 -1.810; 0.082; -2.181; 1.270; 1.141; 1.400 0.0091 sig
SECONDARY
Temporal Control Performance (Reaction Time)		 15.700; 11.987; -2.244; -18.172; -16.540; -23.348 0.0211 sig
SECONDARY
Contextual Control Performance (Reaction Time)		 197.700; 185.443; 160.900; 163.774; 146.982; 132.500 0.0344 sig
SECONDARY
Temporal Control x Contextual Control Performance (Reaction Time)		 55.600; 53.162; 53.280; 141.900; 131.227; 125.100 0.0189 sig

Eligibility Criteria

Inclusion Criteria

  • Between the ages of 18 and 30
  • Right-handed
  • Native English speaker or fluent by the age of 6

Exclusion Criteria

  • History of psychiatric disorders
  • History of neurological disorders
  • Receiving medications for psychiatric or neurological disorders
  • Familial history of epilepsy
  • Taking any drugs or medications that are pro-epileptic
  • Metal anywhere in the head excluding the mouth
  • Tinnitus
  • Women who are pregnant
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04464473). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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