N/A N=83 Randomized Single-blind Treatment

Technology Interventions to Improve Outcomes After Knee Replacement

Knee Arthroplasty

Bottom Line

View on ClinicalTrials.gov: NCT04482400 ↗

Enrolled (actual)

Serious AEs

3.6%

Results posted

Mar 2026

Primary outcome: Primary: Objectively Measured (Actigraph) Sedentary Behavior at 2 Months — 659.52; 638.24 minutes/day

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: NEAT!2 (Behavioral); MyKneeGuide (Behavioral)
Age: Adult, Older Adult · 40+ yrs
Sex: All
Sponsor: University of South Carolina
Primary completion: Oct 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Objectively Measured (Actigraph) Sedentary Behavior at 2 Months	659.52; 638.24	—
PRIMARY Objectively Measured (Actigraph) Sedentary Behavior at 5 Months	674.17; 638.62	—
SECONDARY Physical Function	1338.67; 1340.04	—
SECONDARY WOMAC Pain Subscale	3.05; 3.0	—
SECONDARY Total Physical Activity Measured by Actigraph Accelerometers	1532.41; 1442.08	—
SECONDARY Adherence to Calls	4.8; 4.8	—
SECONDARY Adherence to NEAT!2 App	40.3	—
SECONDARY Response to NEAT!2 Prompts	9.7	—
SECONDARY Physical Function Via Chair Stand Test	10.59; 10.39	—

Summary

The purpose of this study is to examine the effects of two technology interventions on health outcomes (e.g., physical activity, sedentary behavior, physical function, pain) after knee replacement at 2 and 5 months .

Eligibility Criteria

Inclusion Criteria

Be 40-79 years of age
Had unilateral knee replacement within last 12 months
Have an Android or iOS smartphone that is accessible and near them the majority of the day
Be willing to download the study applications on their smartphone
Spend at least 7 hours/day sitting
Be English speaking

Exclusion Criteria

Have any contraindications to activity
Have a mobility limiting comorbidity
Have a scheduled surgery within the next 6 months
Do not have ≥4 days of valid accelerometer (>=10 hours) wear at baseline.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04482400). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.