N/A
N=112
Semantic Learning Deficits in School Age Children With Developmental Language Disorder
Developmental Language Disorder
Bottom Line
View on ClinicalTrials.gov: NCT04508699 ↗Enrolled (actual)
112
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcome: Primary: Mean Percent Correct Semantic Meaning Identification — 73.6; 75.12; 77.1; 82.3 percentage of correct responses — p=0.36
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- semantic learning (Other)
- Age
- Pediatric · 10+ yrs
- Sex
- All
- Sponsor
- San Diego State University
- Primary completion
- May 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Percent Correct Semantic Meaning Identification |
73.6; 75.12; 77.1; 82.3 | 0.36 |
| PRIMARY N400 Amplitude - Sentence 1 |
-.1; -.27 | <0.05 sig |
| PRIMARY Theta Changes |
.0521; .121 | <0.05 sig |
| PRIMARY N400 Amplitude - Sentence 2 |
-0.1; 0.075 | <0.05 sig |
| PRIMARY N400 Amplitude - Sentence 3 |
0.221; .662 | <0.05 sig |
| SECONDARY General Language Level |
73.2; 110.9 | <0.00001 sig |
| SECONDARY Nonverbal Cognition |
86.2; 106.93 | <0.00001 sig |
| SECONDARY Nonword Repetition Task |
83.9; 92.9 | <0.00001 sig |
Summary
School age children with developmental language disorder (DLD) have known semantic learning deficits but what is less well understood is why semantic learning is difficult for these children. This project will combine behavioral and brain methods to investigate the cognitive and linguistic processes underlying semantic learning in children with DLD compared to typically developing peers. The outcomes will have implications for semantic learning intervention approaches in DLD.
Eligibility Criteria
Inclusion Criteria
- history of typical language development or history of language or literacy difficulties
- must be willing to wear EEG cap
- must be able to sit still for 1.5 hours to complete experimental tasks
- must be literate
Exclusion Criteria
- neurological disorders (i.e., ASD, ADHD)
- significant neurological history (i.e., head injury, epilepsy)
- left handedness
- primary language other than English
- medication other than over-the-counter allergy medications
- and/or nonverbal IQ less than 70
Data sourced from ClinicalTrials.gov (NCT04508699). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.