N/A
Completed N=1,410
Pragmatic Trial of Messaging to Providers About Treatment of Heart Failure
Source: ClinicalTrials.gov NCT04514458 ↗Enrolled (actual)
1,410
Serious AEs
0.0%
Results posted
Jul 2025
Primary outcomePrimary: Percentage of Patients With Heart Failure With Reduced Ejection Fraction (HFrEF) With an Increase in Prescribed HFrEF Therapy — 176; 117 Participants
Summary
A randomized controlled trial to compare the efficacy of an electronic health record-based alert informing providers about evidence-based medications for HFrEF versus usual care (no alert) in outpatient clinics across a single health system.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percentage of Patients With Heart Failure With Reduced Ejection Fraction (HFrEF) With an Increase in Prescribed HFrEF Therapy |
176; 117 | — |
| SECONDARY Percentage of Patients on Beta Blockers |
606; 521 | — |
| SECONDARY Percentage of Patients on ACE Inhibitors |
83; 92 | — |
| SECONDARY Percentage of Patients on ARBs |
111; 85 | — |
| SECONDARY Percentage of Patients on ARNIs |
334; 285 | — |
| SECONDARY Percentage of Patients on MRAs |
232; 203 | — |
| SECONDARY Percentage of Patients on SGLT2 Inhibitors |
144; 103 | — |
| SECONDARY Rate of One-year All-cause Mortality |
75; 68 | — |
| SECONDARY Rate of 30-day Hospital Admission |
47; 63 | — |
| SECONDARY Rate of 30-day All-cause Emergency Department Visits |
86; 77 | — |
| SECONDARY Total Six-month Healthcare Costs |
— | — |
| SECONDARY Percentage of Filled Prescriptions |
— | — |
| SECONDARY Medication Dose of Any Prescribed Beta Blocker |
— | — |
| SECONDARY Medication Dose of Any Prescribed ACEi |
— | — |
| SECONDARY Medication Dose of Any Prescribed ARB |
— | — |
| SECONDARY Medication Dose of Any Prescribed ARNI |
— | — |
| SECONDARY Medication Dose of Any Prescribed MRA |
— | — |
| SECONDARY Medication Dose of Any Prescribed SGLT2 Inhibitor |
— | — |
Eligibility Criteria
Patient Inclusion Criteria:
- Age 18 or over
- Seen in eligible internal medicine or cardiology clinic
- Left ventricular ejection fraction less than or equal to 40%
- Registered in the Yale Heart Failure Registry
Patient Exclusion Criteria:
- Opted out of EHR-based research
- Under hospice care
- Already receiving each targeted class of evidence-based HFrEF medical therapy
Selection of Providers:
- Practicing at an eligible internal medicine or cardiology clinic
- High frequency of visits by eligible patients based on retrospective chart review
Data sourced from ClinicalTrials.gov (NCT04514458). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.