N/A N=12 Basic Science

The Impact of Oral Ethanol and Vaped Ethanol on the Evaluation of Impairment

Electronic Cigarette Use

Bottom Line

View on ClinicalTrials.gov: NCT04522973 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2025

Primary outcome: Primary: Blood Alcohol Concentration — 0; 0; 0; 0 percent alcohol

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Beverage with ethanol and E-cigarette liquid with ethanol (Other); Beverage with ethanol and E-cigarette liquid without ethanol (Other); Beverage without ethanol and E-cigarette liquid with ethanol (Other); Beverage without ethanol and E-cigarette liquid without ethanol (Other)
Age: Adult · 21+ yrs
Sex: All
Sponsor: Virginia Commonwealth University
Primary completion: Jul 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Blood Alcohol Concentration	0; 0; 0; 0; 0; 0	—
PRIMARY Breath Alcohol Concentration	0; 0; 0; 0; 0; 0	—
PRIMARY Oral Fluid Alcohol Concentration (OFAC)	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarker (5-Hydroxytryptophol) in Blood	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (5-Hydroxyindoleacetic Acid) in Blood	80; 90; 44; 121; 91; 34	—
PRIMARY Ethanol Biomarkers (Ethyl Sulfate) Analyzed in Blood/ E-cig Containing Ethanol	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Phosphatidylethanol 16:0-18:1) in Blood	402; 416; 647; 409; 338; 304	—
PRIMARY Ethanol Biomarkers (Phosphatidylethanol 16:0-18:2) in Blood	894; 1013; 1256; 938; 549; 549	—
PRIMARY Ethanol Biomarkers (5-Hydroxytryptophol Glucuronide) Analyzed in Blood	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (5-Hydroxytryptophol) in Blood	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (5-Hydroxytryptophol) in Analyzed in Oral Fluid	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (5-Hydroxyindoleacetic Acid) Analyzed in Oral Fluid	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Ethyl Sulfate) Analyzed in Oral Fluid	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Phosphatidylethanol 16:0-18:1) Analyzed in Blood	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Phosphatidylethanol 16:0-18:2) in Oral Fluid	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Ethyl Glucuronide) Analyzed in Blood	0; 0; 0; 0; 0; 0	—
PRIMARY Ethanol Biomarkers (Ethyl Glucuronide) Analyzed in Oral Fluid	0; 0; 0; 0; 0; 0	—
SECONDARY Horizontal Gaze Nystagmus	0; .9; .7; .3; .4; .9	—
SECONDARY Walk and Turn Test	.6; .9; .9; .6; .4; .9	—
SECONDARY One Leg Stand Test	.6; .7; .4; .7; .3; 0	—

Summary

The purpose of this research study is to determine if ethanol-containing e-cigarettes impact ethanol breath, blood or oral fluid tests, field sobriety tests, or other tests of sobriety. Ethanol is a common part of e-cigarette liquids.

Eligibility Criteria

Inclusion Criteria

e-cigarette users
alcohol consumers
willing to provide informed consent
able to attend the lab sessions as needed
agree to use designated products according to study protocol.

Exclusion Criteria

Women who are breast-feeding or test positive for pregnancy (by urinalysis) at screening.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04522973). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.