Phase 2
N=56
Coronavirus Disease 2019 (COVID-19) Antibody Plasma Research Study in Hospitalized Patients
COVID-19
Bottom Line
View on ClinicalTrials.gov: NCT04524507 ↗Enrolled (actual)
56
Serious AEs
30.9%
Results posted
Nov 2021
Primary outcome: Primary: Total Number of Serious Adverse Events (SAE) Through Study Day 14 — 0; 0 Serious Adverse Events
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- High-titer Convalescent COVID-19 Plasma (CCP1) (Biological); Standard-titer Convalescent COVID-19 plasma (CCP2) (Biological)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of North Carolina, Chapel Hill
- Primary completion
- Jan 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Total Number of Serious Adverse Events (SAE) Through Study Day 14 |
0; 0 | — |
| PRIMARY Median Time to Hospital Discharge (or Discharge Equivalent) Following First Dose of CCP |
5; 7 | — |
Summary
The purpose of this research study is to find out if CCP is safe and to determine the safest and most effective level of anti-viral antibody when given to people admitted to the hospital with confirmed COVID-19 infection. Participants enrolled on this study will be transfused with 2 units of CCP through an IV. These units will be given one at a time 4 to 24 hours apart. Participants will be randomized to receive either 2 units with standard antibody levels as recommended by the FDA or 2 units with an antibody level higher than that recommended by the FDA. This study is experimental and CCP is investigational and has not been approved by the FDA for the treatment of COVID-19. The CCP is collected per FDA guidelines from persons recovered from COVID-19 infection. The plasma contains antibodies and possibly other properties that inhibit the virus. The investigators do not know if the level of antibodies present in the CCP will make a difference in how the participant's body is able to fight the infection and hope to learn that in this study.
Eligibility Criteria
Inclusion Criteria
- Age at least 18 years
- Ability and willingness of participant or Legally Authorized Representative (LAR) to give written informed consent.
- Laboratory confirmed diagnosis of infection with SARS-CoV-2 by PCR
- Hospitalized for COVID-19 with one or more respiratory or gastrointestinal (GI) symptoms:
- COVID-19 associated respiratory symptoms include but are not limited to: cough, shortness of breath, difficulty breathing, or sore throat
- COVID-19 associated GI symptoms include but are not limited to: loss of taste, loss of sense of smell, diarrhea, nausea, or vomiting,
Note: Respiratory and GI symptoms other than those listed above, must be noted as acceptable and signed by study PI or designee.
Exclusion Criteria
- Receipt of pooled immunoglobulin in past 30 days
- Current or prior enrollment in a SARS-CoV-2 antibody or T-cell therapeutic study.
Note: Patients enrolled on other randomized controlled trials of pharmaceutical and/or non-pharmaceutical interventions for COVID and meeting eligibility criteria will not be excluded, as determined by study PI (or designee) on a case-by-case basis and as allowed by eligibility criteria of the other trials.
- Contraindication to transfusion or history of prior reactions to transfusion blood products. This may include religious or cultural objections to receiving blood products and transfusions.
- ABO-compatible titered plasma is not available
- > 10 days from noted COVID-related subjective or objective fever at randomization. Patients without subjective or objective fever, > 10 days from symptom onset as determined by study PI.
Data sourced from ClinicalTrials.gov (NCT04524507). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.