Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19

Inclusion Criteria

• Age from 18 to 65 years of age, inclusive, at the time of signing the informed consent.
• Willing and able to provide informed consent.
• Women of reproductive potential must be using a highly effective method of contraception for at least 28 days prior to enrolment and must be able and willing to continue its use throughout the duration of the study.
• Men must agree to use condoms when engaging in heterosexual sex during the study and for the period up to 91 days after the last dose of study medication. Men who are not randomized to a treatment arm including favipiravir (or another arm identified as having teratogenic potential through semen) will no longer need to adhere to this after randomization.
• Laboratory confirmed SARS-CoV-2 infection, and any of the following self-reported symptoms within 72 hours prior to randomization: fever or chills, cough, myalgia, sore throat, shortness of breath, or new onset of anosmia or ageusia.
• Body weight ≥45 kg.
• Access to reliable video conference, telephone, direct/text messaging, or other device permitting real-time, reliable information transfer.

Exclusion Criteria

• Pregnant or lactating women.
• Known hypersensitivity or specific contraindications to the use of any of the active drugs in the treatment arms, or similar compounds.
• Signs of respiratory distress prior to randomization, including:
• respiratory rate >24 breaths/min
• SpO2 470 msec for females, or >450 msec for males, at screening.
• Serum potassium <3.5 mmol/L at screening.
• History of clinically significant cardiovascular disease (including arrhythmias, QT-interval prolongation, torsades de pointes (TdP), history of coronary artery disease with graft or stent procedures/surgery, cardiac failure [class 2 or higher using the New York Heart Association functional classification]).
• Known chronic kidney disease (Stage IV or receiving dialysis).
• Known cirrhosis (Child-Pugh Class B or greater).
• Known macular degeneration, or other known retinal diseases, or 4-aminoquinolone-induced visual impairment.
• Currently receiving, or recently received (within 60 days prior to randomization) treatment with any of the drugs in the treatment arms.
• Currently receiving, or recently received (within 30 days prior to randomization) treatment with any antimalarial drugs.
• Currently on treatment with drugs with known arrhythmogenic potential, or those known to induce significant QT-interval prolongation or TdP, as detailed in Appendix 6.
• Currently on treatment for tuberculosis (or on treatment with rifampicin for any other indication), or on treatment with a protease inhibitor-based antiretroviral regimen, or efavirenz, or carbamazepine.
• Inability/unlikely to be in the study area for the duration of the 28 day follow-up period.
• Any surgical or medical condition which might significantly alter the absorption, distribution, metabolism, or excretion of drugs, or which may jeopardize the safety of the volunteer or the objectives of the study. The Investigator should make this determination in consideration of the volunteer's medical history.
• Personnel (e.g. investigator, sub-investigator, research assistant, pharmacist, study coordinator or anyone mentioned in the delegation log) directly involved in the conduct of the study.
• Participant is judged by the Investigator to be at significant risk of failing to comply with the provisions of the protocol as to cause harm to self or seriously interfere with the validity of the study results.