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N/A N=17 Randomized Double-blind Other

Task Augmentation of Transcranial Magnetic Stimulation (TMS)

Healthy

Bottom Line

View on ClinicalTrials.gov: NCT04586205 ↗
Enrolled (actual)
17
Serious AEs
0.0%
Results posted
May 2025
Primary outcome: Primary: Sternberg Sorting Task (SST) at Baseline — 0.85; 0.64; 0.87; 0.66 proportion of correct responses — p=0.024

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
active TMS (Device); sham TMS (Device); IASP Task (Behavioral); SST Task (Behavioral); MRI (Other)
Age
Adult · 18+ yrs
Sex
All
Sponsor
University of Pennsylvania
Primary completion
Mar 2020

Outcome Measures

OutcomeResultp-value
PRIMARY
Sternberg Sorting Task (SST) at Baseline		 0.85; 0.64; 0.87; 0.66 0.024 sig
PRIMARY
International Affective Picture System (IAPS)		 0.69; 0.52; 0.67; 0.59 0.18
SECONDARY
International Affective Picture System (IAPS) at Post-intervention (Active/Sham)		 178; 121; 193; 223 0.19
SECONDARY
Comparing the Impact of Sternberg Sort Task (SST), the Working Memory Task and International Affective Picture System (IAPS) Emotional Task on TMS-Induced DLPFC Activation; Post-intervention (Active/Sham)		 0.266; 0.183; 0.156; 0.056; 0.232; 0.135 0.67

Summary

This pilot, within-subjects, randomized proof-of-concept study investigates the effects of activating the DLPFC promotion system on TMS treatment outcomes. Twenty-five healthy volunteers will participate in four sessions involving either active or sham repetitive transcranial magnetic stimulation (rTMS). Using anatomically guided TMS paired with cognitive tasks, the study tests the hypothesis that cognitive paired associative stimulation enhances cortical responses. For this pilot study, we are focusing only on the augmentation of TMS with the IASP task.

Eligibility Criteria

Inclusion Criteria

  • Gender, inclusive
  • 18 60 years of age
  • Right-handed
  • No history of meeting Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria for any diagnosis
  • Normal cognition
  • Patients must be able to read and understand English
  • Participants must be able to provide consent

Exclusion Criteria

  • Pregnancy (Female participants)
  • Outside age range
  • Meets DSM criteria for any diagnosis
  • Unable to have an MRI scan
  • Medical condition that interferes with the collection or interpretation of MRI data
  • Implanted devices such as: aneurysm clip or cardiac pacemaker
  • History of stroke, epilepsy, or brain scarring
  • Cognitive impairment
  • Recent use of psychoactive medications, as determined by investigators
  • Otherwise determined by investigator to be unfit for participation
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04586205). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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