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N/A N=31,265 Randomized Health Services Research

HPV Vaccine Communication ECHO for Primary Care Clinics

Human Papillomavirus Vaccines · Adolescent Health Services

Enrolled (actual)
31,265
Serious AEs
0.0%
Results posted
Feb 2026
Primary outcome: Primary: HPV Vaccination (≥1 Dose), 11-14 Year Olds at 12 Months — 3189; 3833; 4260 Participants

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Project ECHO (Other); Announcement Approach Training (Other); Recall notices (Other)
Age
Adult, Older Adult · 18+ yrs
Sex
All
Sponsor
Milton S. Hershey Medical Center
Primary completion
Sep 2024

Outcome Measures

OutcomeResultp-value
PRIMARY
HPV Vaccination (≥1 Dose), 11-14 Year Olds at 12 Months
3189; 3833; 4260
SECONDARY
HPV Vaccination (≥1 Dose), 11-14 Year Olds at 3 Months
2483; 1759; 4083
SECONDARY
HPV Vaccination (≥1 Dose), 11-14 Year Olds at 6 Months
2584; 1831; 4177
SECONDARY
HPV Vaccination (≥1 Dose), 11-14 Year Olds at 9 Months
2744; 1888; 4102
SECONDARY
HPV Vaccination (Completion), 11-14 Year Olds at 3 Months
1517; 1063; 3075
SECONDARY
HPV Vaccination (Completion), 11-14 Year Olds at 6 Months
1655; 1156; 3249
SECONDARY
HPV Vaccination (Completion), 11-14 Year Olds at 9 Months
1817; 1232; 3180
SECONDARY
HPV Vaccination (Completion), 11-14 Year Olds at 12 Months
1984; 1946; 3432
SECONDARY
HPV Vaccination (≥1 Dose), 15-17 Year Olds at 3 Months
1965; 1801; 3182
SECONDARY
HPV Vaccination (≥1 Dose), 15-17 Year Olds at 6 Months
1976; 1805; 3158
SECONDARY
HPV Vaccination (≥1 Dose), 15-17 Year Olds at 9 Months
1997; 1812; 3185
SECONDARY
HPV Vaccination (≥1 Dose), 15-17 Year Olds at 12 Months
2397; 3684; 3176
SECONDARY
HPV Vaccination (≥1 Dose), 11-14 Year Olds at 12 Months by Sex
1628; 1860; 2079; 1561; 1973; 2181
SECONDARY
HPV Vaccination (≥1 Dose), 15-17 Year Olds at 12 Months by Sex
1210; 1846; 1585; 1187; 1838; 1591

Summary

The safe, highly-effective human papillomavirus (HPV) vaccine remains underused in the US; only 51% of 13- to 17-year-old girls and boys were up-to-date by 2018. The Announcement Approach Training is effective in increasing HPV vaccine uptake during the clinic visit by training providers to make strong vaccine recommendations and answer parents' common questions. Systems communication like recall notifications also improve vaccination by reducing missed clinical opportunities. Although never tested to support HPV vaccination, the ECHO (Extension for Community Healthcare Outcomes) Model is a proven implementation strategy to promote capacity exchange between health care experts at academic centers and primary care providers at the front line of rural community health care. The trial will test the effectiveness of two ECHO-delivered HPV vaccination communication interventions versus control: HPV ECHO will provide Announcement Approach training, and HPV ECHO+ will provide training plus recall notices to communicate with parents who initially decline vaccination.

Eligibility Criteria

Clinics in cluster RCT (main study)

Inclusion Criteria

  • Family medicine or pediatric clinic in Pennsylvania
  • Having at least 100 active patients, ages 11-14.

Exclusion Criteria

  • Primary care clinic outside Pennsylvania
  • Participated in HPV vaccine communication or quality improvement research either through Penn State or another institution in the last 12 months.

Parents in nested study survey

Inclusion criteria

  • Parent or guardian of an adolescent ages 11-17
  • Adolescent has not yet started HPV vaccination
  • Adolescent receive primary care at participating clinic

Exclusion criteria

  • Not the parent or guardian of an adolescent ages 11-17
  • Adolescent already initiated HPV vaccination
  • Adolescent does not receive primary care at participating clinic
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04587167). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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