N/A
Completed N=9
Assessing the Feasibility of N-of-1 Trials in Children With Hypertension and Chronic Kidney Disease
Hypertension · Chronic Kidney Diseases
Source: ClinicalTrials.gov NCT04591171 ↗
Enrolled (actual)
9
Serious AEs
0.0%
Results posted
Mar 2023
Primary outcomePrimary: Change in 24-hour Mean Arterial Pressure (MAP) — 1.4 mmHg
Summary
The purpose of this study to test whether n-of-1 trial-guided clinical decision-making improves blood pressure control in hypertensive children with chronic kidney disease (CKD) and end-stage renal disease (ESRD).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in 24-hour Mean Arterial Pressure (MAP) |
1.4 | — |
| SECONDARY Number of Participants With Target Blood Pressure |
3 | — |
| SECONDARY Number of Participants With Target Blood Pressure |
3 | — |
Eligibility Criteria
Inclusion Criteria
- hypertension
- CKD stage 2-5
- requiring antihypertensive medication per clinician judgement.
Exclusion Criteria
- renal transplant anticipated or occurred within 6 months of screening
- transfer out of our practice setting anticipated within 6 months
- unable to complete 24 hour arterial blood pressure monitoring (ABPM) due to developmental or behavioral limitations
Data sourced from ClinicalTrials.gov (NCT04591171). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.