Phase 3 N=3,395 Randomized Treatment

Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data

Perioperative Optimization

Bottom Line

View on ClinicalTrials.gov: NCT04606264 ↗

Enrolled (actual)

3,395

Serious AEs

0.0%

Results posted

May 2026

Primary outcome: Primary: 30 Day Hospital Free Days — 27; 27; 26; 27 Number of hospital free days

Study Design & Population

Study type: Interventional
Phase: Phase 3
Interventions: Neuraxial Analgesia (Drug); Regional Block 1: Paravertebral (Drug); Perphenazine (Drug); Aprepitant (Drug); Dimenhydrinate (Drug); Ondansetron 4 MG (Drug); Dexamethasone (Drug); Regional Block 2: QL1 (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Jennifer Holder-Murray
Primary completion: Mar 2025

Outcome Measures

Outcome	Result	p-value
PRIMARY 30 Day Hospital Free Days	27; 27; 26; 27; 27; 27	—
SECONDARY Change in Postoperative Nausea and Vomiting (PONV) by Measurement Incidences of Emesis Within 24 Hours Post Surgery	271; 246	—
SECONDARY Change in the Rate of Postoperative Opioid Use by Measurement of Oral Morphine Equivalents (OME) Measured 24 Hours After Surgery	3.0; 3.7; 3.6; 2.8; 2.7	—

Summary

This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after surgery in all patients with elective surgical encounters at UPMC who meet eligibility criteria. The ERP domain seeks to enhance recovery by optimizing strategies of perioperative care through evaluating combinations of perioperative treatment, which consists of preoperative, intraoperative and postoperative care. Optimal combinations of perioperative care will be generated and analyzed to determine the best outcomes for patients as defined by reduction in hospital free days, reduction in postoperative nausea and vomiting, and improved pain control.

Eligibility Criteria

Inclusion Criteria

Patient is seen in preoperative appointment prior to surgery
≥ 18 years of age
Anticipated overnight hospital stay
Scheduled for elective abdominal surgery that utilizes ERP PowerPlans - placed into the patient's electronic chart at least one night before surgery
ERP Abdominal Complex Pathway PowerPlan (used for colorectal and gastrointestinal surgery)
ERP Bariatric Surgery Pathway PowerPlan
ERP Gynecology Oncology Pathway PowerPlan
ERP Whipple/Pancreas Pathway PowerPlan
ERP Open Liver Resection Pathway PowerPlan
Surgery is scheduled for one of the following UPMC sites:
UPMC Presbyterian Hospital
UPMC Passavant Hospital
UPMC Magee-Women's Hospital

Exclusion Critera

Death is deemed to be imminent or inevitable
Patient is pregnant < 18 years of age
Patients undergoing emergent/urgent surgery
Patients that are pregnant
Patients that have an eligible PowerPlan ordered less than one night before surgery

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04606264). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.