Phase 3
Completed N=3,395
Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data
Perioperative Optimization
Source: ClinicalTrials.gov NCT04606264 ↗
Enrolled (actual)
3,395
Serious AEs
0.0%
Results posted
May 2026
Primary outcomePrimary: 30 Day Hospital Free Days — 27; 27; 26; 27 Number of hospital free days
◆ Published Evidence
Emerging
8citations · ~3 / year
REMAP Periop: a randomised, embedded, multifactorial adaptive platform trial protocol for perioperative medicine to determine the optimal enhanced recovery pathway components in complex abdominal surgery patients within a US healthcare system.
Summary
This REMAP Periop ERP domain study falls under the Periop Core Protocol, which compares the different recommended strategies for enhancing recovery through the use of various standard of care treatments before, during and after surgery in all patients with elective surgical encounters at UPMC who meet eligibility criteria.
The ERP domain seeks to enhance recovery by optimizing strategies of perioperative care through evaluating combinations of perioperative treatment, which consists of preoperative, intraoperative and postoperative care. Optimal combinations of perioperative care will be generated and analyzed to determine the best outcomes for patients as defined by reduction in hospital free days, reduction in postoperative nausea and vomiting, and improved pain control.
Linked Publications
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REMAP Periop: a randomised, embedded, multifactorial adaptive platform trial protocol for perioperative medicine to determine the optimal enhanced recovery pathway components in complex abdominal surgery patients within a US healthcare system.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY 30 Day Hospital Free Days |
27; 27; 26; 27; 27; 27 | — |
| SECONDARY Change in Postoperative Nausea and Vomiting (PONV) by Measurement Incidences of Emesis Within 24 Hours Post Surgery |
271; 246 | — |
| SECONDARY Change in the Rate of Postoperative Opioid Use by Measurement of Oral Morphine Equivalents (OME) Measured 24 Hours After Surgery |
3.0; 3.7; 3.6; 2.8; 2.7 | — |
Eligibility Criteria
Inclusion Criteria
- Patient is seen in preoperative appointment prior to surgery
- ≥ 18 years of age
- Anticipated overnight hospital stay
- Scheduled for elective abdominal surgery that utilizes ERP PowerPlans - placed into the patient's electronic chart at least one night before surgery
- ERP Abdominal Complex Pathway PowerPlan (used for colorectal and gastrointestinal surgery)
- ERP Bariatric Surgery Pathway PowerPlan
- ERP Gynecology Oncology Pathway PowerPlan
- ERP Whipple/Pancreas Pathway PowerPlan
- ERP Open Liver Resection Pathway PowerPlan
- Surgery is scheduled for one of the following UPMC sites:
- UPMC Presbyterian Hospital
- UPMC Passavant Hospital
- UPMC Magee-Women's Hospital
Exclusion Critera
- Death is deemed to be imminent or inevitable
- Patient is pregnant < 18 years of age
- Patients undergoing emergent/urgent surgery
- Patients that are pregnant
- Patients that have an eligible PowerPlan ordered less than one night before surgery
Data sourced from ClinicalTrials.gov (NCT04606264) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.