N/A
N=23
Long Sleep Duration and Vascular Function
Sleep
Bottom Line
View on ClinicalTrials.gov: NCT04679051 ↗Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Jan 2023
Primary outcome: Primary: Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed — -1.5; 0.5 mm Hg — p=0.36
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sleep duration (Behavioral)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Texas Tech University
- Primary completion
- Jun 2021
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Wake in Central Aortic Pulse Pressure After 11 Hours in Bed |
-1.5; 0.5 | 0.36 |
| PRIMARY Change in Cerebral Vascular Reactivity After 11 Hours in Bed |
11.9; 11.3 | 0.51 |
| PRIMARY Change in Peak Reactive Hyperemia After 11 Hours in Bed |
20.8; 24.2 | 0.03 sig |
| PRIMARY Change in Arterial Stiffness After 11 Hours in Bed |
6.84; 6.96 | 0.29 |
| SECONDARY Change in Spatial Orientation After Aerobic Exercise |
7.0; 3.9 | <0.001 sig |
| SECONDARY Change in Executive Function After Aerobic Exercise |
4.5; 2.4 | 0.04 sig |
| SECONDARY Change in Mental Flexibility After Aerobic Exercise |
2.8; 1.6 | 0.02 sig |
Summary
Sleep duration has received much attention in recent years due to strong evidence that not enough sleep can increase risk for a number of diseases and disorders. Research is emerging that too much sleep also has a negative impact on health, particularly higher risk for myocardial infarction and stroke. The investigators hypothesize that long duration sleep has the ability to impair peripheral and cerebral vascular function in middle-aged to older adults.
Eligibility Criteria
Inclusion Criteria
- recreationally active
- reporting no recent history of sleep problems
- not taking sleep-inducing medication
- not diabetic (fasting blood glucose <126 mg/dL)
Exclusion Criteria
- show symptoms of insomnia
- smoke
- have a personal history of stroke or diabetes
- take birth control pills
Data sourced from ClinicalTrials.gov (NCT04679051). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.