Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN)

Inclusion Criteria

• Covid-19 positive by polymerase chain reaction (PCR) testing;
• Participant must be able to evaluate their symptoms and report them in the symptoms diary;
• Patients must be able to take their oral temperature daily with an electronic thermometer provided to them with study materials;
• Males and females, at least 18 years of age, capable and willing to provide informed consent;
• Female patient is either not of childbearing potential, defined as postmenopausal for at least 1 year or surgically sterile, or is of childbearing potential and practicing at least one method of contraception and preferably two complementary forms of contraception including a barrier method (e.g. male or female condoms, spermicides, sponges, foams, jellies, diaphragm, intrauterine device (IUD)) throughout the study;
• Patient must have received a diagnosis of COVID-19 infection within the last 48 hours and have one or more symptoms;
• Outpatient setting (not currently hospitalized or under immediate consideration for hospitalization);
• Patient must be able and willing to comply with the requirements of this study protocol.

Exclusion Criteria

• Patient currently hospitalized or under immediate consideration for hospitalization;
• Patient currently in shock or with hemodynamic instability;
• Patient undergoing chemotherapy for cancer;
• Patient is unable to take oral temperature using an electronic thermometer;
• Patient who received at least one dose of the COVID-19 vaccine;
• Female patient who is pregnant or breast-feeding or is considering becoming pregnant during the study;
• People taking anticoagulant/antiplatelet medications, those with bleeding disorders, and people two weeks before or after surgery;
• Patient is considered by the investigator, for any reason, to be an unsuitable candidate for the study;
• Regular consumption of natural products containing more than 150 mg of hesperidin or regular consumption of more than 1 glass of orange juice per day;
• Known allergy to any of the medicinal and non-medicinal ingredient: hesperidin, microcrystalline cellulose, magnesium stearate.