N/A
N=579
An Observational Study of Beta-Blocker Use in Patients With COPD and Acute MI
Pulmonary Disease, Chronic Obstructive
Bottom Line
View on ClinicalTrials.gov: NCT04717492 ↗Enrolled (actual)
579
Serious AEs
34.7%
Results posted
Jan 2025
Primary outcome: Primary: Prevalence of COPD in Patients Admitted to the Hospital With an Acute Myocardial Infarction (AMI) — 562 Participants
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- Observational (Other)
- Age
- Adult, Older Adult · 35+ yrs
- Sex
- All
- Sponsor
- University of Minnesota
- Primary completion
- May 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Prevalence of COPD in Patients Admitted to the Hospital With an Acute Myocardial Infarction (AMI) |
562 | — |
| PRIMARY Forced Expiratory Volume (FEV1), L; Post-bronchodilator |
1.6; 1.7 | — |
| PRIMARY FEV1 % Predicted; Post-bronchodilator |
51.5; 67.0 | — |
| PRIMARY Number of Participants With Prescriptions for Home Oxygen |
16; 78 | — |
| PRIMARY Number of Participants That Received a Course of Systemic Corticosteroids and/or Antibiotics in Past Year |
21; 111 | — |
| PRIMARY Number of Courses of Systemic Corticosteroids and/or Antibiotics in Past Year |
1.0; 1.0 | — |
| PRIMARY Respiratory Episodes Requiring Care in the Emergency Department in Past Year |
11; 69 | — |
| PRIMARY Respiratory Episodes Leading to Hospitalization in Past Year |
10; 56 | — |
| PRIMARY Number of Hospitalizations in Past Year |
1.0; 1.0 | — |
| PRIMARY Respiratory Episodes Requiring Intubation in Past Year |
0; 4 | — |
| PRIMARY Time to Death, or First Hospitalization or Revascularization Event |
19; 37.5 | 0.962 |
| PRIMARY Risk of Death, Hospitalization or Revascularization Event |
35; 195 | — |
| SECONDARY Time to Cardiovascular Disease (CVD) Related Death or First CVD-related Hospitalization/Revascularization Event |
23.5; 37.5 | 0.694 |
| SECONDARY Risk of Cardiovascular Disease (CVD) Related Death or First CVD-related Hospitalization/Revascularization Event |
20; 114 | — |
| SECONDARY Time to Respiratory/COPD-related Death or Hospitalization Event |
93; 61 | 0.476 |
| SECONDARY Risk of Respiratory/COPD-related Death or Hospitalization Event |
10; 45 | — |
Summary
The study is a prospective, observational study of patients admitted to the BLOCK COPD network hospitals with acute AMI and Chronic Obstructive Pulmonary Disease (COPD) to determine the prevalence of COPD in patients admitted to the hospital with an acute myocardial infarction (AMI) and to characterize the phenotypic expression and severity of their underlying lung disease. Patients with will be identified via the EMR. 571 participants will be enrolled.
Eligibility Criteria
Inclusion Criteria
- Willing and able to provide informed consent (applicable for Option 1 and 2 only)
- Men and women age 35 or older
- Admitted to hospital from the Emergency Department or by hospital to hospital transfer with a primary diagnosis of AMI
- Undergo cardiac catheterization for AMI
- EMR-documented COPD
Exclusion Criteria
- Cognitive disorder that in the judgment of the investigator impairs understanding of the study objectives or assessments (applicable for Option 1 only)
- Vulnerable populations, including prisoners and pregnant women
Data sourced from ClinicalTrials.gov (NCT04717492). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.