N/A N=8 Basic Science

Sensorimotor Imaging for Brain-Computer Interfaces

Functional Neuroimaging

Bottom Line

View on ClinicalTrials.gov: NCT04723823 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Aug 2024

Primary outcome: Primary: Peak Activity Volume: Right D1 Attempt Movement Activity at S1 - SCI — 893.6 mm^3

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Motor or sensory imagery with fMRI (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Pittsburgh
Primary completion: May 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY Peak Activity Volume: Right D1 Attempt Movement Activity at S1 - SCI	893.6	—
PRIMARY Peak Activity Volume: Right D2 Attempt Movement Activity at S1 - SCI	549	—
PRIMARY Peak Activity Volume: Right D3 Attempt Movement Activity at S1 - SCI	391.75	—
PRIMARY Peak Activity Volume: Right D4 Attempt Movement Activity at S1 - SCI	221.5	—
PRIMARY Peak Activity Volume: Right Hand Grasp Overt/Attempt Movement Activity at S1 - SCI	2588.8	—
PRIMARY Peak Activity Volume: Left Ankle Overt/Attempt Movement Activity at M1 - ALS	437	—
PRIMARY Peak Activity Volume: Right Toe Overt/Attempt Movement Activity at M1 - ALS	251.5	—
PRIMARY Peak Activity Volume: Right Hand Grasp Overt/Attempt Movement Activity at M1 - ALS	238.5	—
PRIMARY Location of Peak Activity (X-coordinate) for Right D1 Attempt Movement - SCI	176.4	—
PRIMARY Location of Peak Activity (Y-coordinate) for Right D1 Attempt Movement - SCI	67	—
PRIMARY Location of Peak Activity (Z-coordinate) for Right D1 Attempt Movement - SCI	103.2	—
PRIMARY Location of Peak Activity (X-coordinate) for Left Ankle Overt/Attempt Movement Activity - ALS	123.33	—
PRIMARY Location of Peak Activity (Y-coordinate) for Left Ankle Overt/Attempt Movement Activity - ALS	63.67	—
PRIMARY Location of Peak Activity (Z-coordinate) for Left Ankle Overt/Attempt Movement Activity - ALS	87.67	—
PRIMARY Location of Peak Activity (X-axis): Right Hand Grasp - SCI	163.6	—
PRIMARY Location of Peak Activity (Y-axis): Right Hand Grasp - SCI	59.4	—
PRIMARY Location of Peak Activity (Z-axis): Right Hand Grasp - SCI	93	—

Summary

The investigators will use fMRI to map movement activity in motor and somatosensory cortex using enriched imagery in people with chronic tetraplegia. The investigators expect that somatotopic organization of movement activity will be preserved in people with upper limb impairments, which can be quantified using the strength, area, and location of sensorimotor activity. Accurate mapping of the motor and somatosensory cortices using covert stimuli will help guide brain-computer interface (BCI) electrode design and placement. Moreover, these advanced mapping procedures will provide new insights into the functional interactions between sensory and motor areas of the brain after injury or disease.

Eligibility Criteria

Inclusion Criteria

Age 18 or older
Normal or corrected to normal vision
Impairment of at least one arm/hand as a result of cervical spinal cord injury or amyotrophic lateral sclerosis. The ALS diagnosis should be possible, probable, or definite ALS based on El Escorial criteria.
Decreased or absent sensation or impaired hand movement
Score of <10 on the Short Blessed Test cognitive assessment

Exclusion Criteria

Pacemaker, baclofen pump, cochlear implant or other electronic implanted device
Metallic implant that is unsafe for 3T MRI
Pregnant females
Individuals who weigh over 300 pounds (because of MRI risks/space)
Individuals who have difficulty breathing when laying down (orthopnea)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT04723823). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.