Phase 4
N=108
Antibiotic Resistance In Eye Surgeries
Antibiotic Resistance · Ocular Surface Microbiome · Gut Resistome
Bottom Line
View on ClinicalTrials.gov: NCT04750655 ↗Enrolled (actual)
108
Serious AEs
0.0%
Results posted
Mar 2025
Primary outcome: Primary: Antimicrobial Resistance (AMR) of Conjunctiva at 1 Week — 0; 0; 0 reads per million reads — p=1
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Moxifloxacin (Topical) (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of California, San Francisco
- Primary completion
- Aug 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Antimicrobial Resistance (AMR) of Conjunctiva at 1 Week |
0; 0; 0 | 1 |
| SECONDARY Antimicrobial Resistance (AMR) of Nasopharynx at 1 Week |
0; 0; 0 | — |
| SECONDARY Shannon's Index |
14; 14; 17 | — |
| SECONDARY Simpson's Index |
6; 8; 5 | — |
| SECONDARY Simpson's Index |
6; 8; 5 | — |
Summary
In this study, the investigators seek to determine the effect of antibiotic use post-surgery on antimicrobial resistance. The investigators will be studying adults (aged 18 or older) who will undergo eye surgery at University of California, San Francisco (UCSF). We seek to gain a better understanding of how antibiotic use during the perioperative period influences local and systemic antibiotic resistance at the individual level.
Eligibility Criteria
Inclusion Criteria
- Over 18 years of age
- Undergoing cataract surgeries that would benefit from intracameral antibiotics
- Able to provide swabs
- Able to provide consent
- Surgery of the second eye occurs at least 8 weeks after surgery of the first eye
Exclusion Criteria
- Same-day bilateral cataract surgeries
- On immunosuppression medication such as Prednisone, Methotrexate, Cellcept, or anti-TNF inhibitors within past 3 months
- On systemic antibiotic within past 3 months
- On topical antibiotics within past 8 weeks
- Allergies to fluoroquinolone
- Patients needing glaucoma drainage device or trabeculectomy
- Inability to consent
Data sourced from ClinicalTrials.gov (NCT04750655). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.