N/A
N=38
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Traumatic Brain Injury (TBI) · Chronic Traumatic Encephalopathy (CTE)
Bottom Line
View on ClinicalTrials.gov: NCT04796207 ↗Enrolled (actual)
38
Serious AEs
0.0%
Results posted
May 2025
Primary outcome: Primary: Changes in Brain Biomarkers Due to Sub-concussion Injury - Nf-L — 5.36; 4.82; 6.05; 6.47 pg/ml
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Fish Oil (DPA+EPA 2:1 ratio) Capsules (Dietary_supplement); High Oleic Safflower Oil Capsules (Dietary_supplement)
- Age
- Adult · 18+ yrs
- Sex
- Male
- Sponsor
- University of Arizona
- Primary completion
- Jan 2020
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Changes in Brain Biomarkers Due to Sub-concussion Injury - Nf-L |
5.36; 4.82; 6.05; 6.47; 7.61; 6.21 | — |
| PRIMARY Changes in Sub-concussion Injury Related Inflammation Biomarkers - TNF-α |
1.181; 0.962; 1.039; 0.918 | — |
| PRIMARY Changes in Sub-concussion Injury Related Inflammation Biomarkers - IL-6 |
2.186; 1.309; 2.338; 2.107; 2.158; 1.761 | — |
Summary
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football athletes.
Eligibility Criteria
Inclusion Criteria
- University of Arizona National Collegiate Athletic Association (NCAA) Division I American football athletes cleared to participate in university athletics as determined by the team physician.
Exclusion Criteria
- Chronic daily anti-inflammatory drugs (>20 d).
- Medications for blood lipids.
- Active fish oil or omega-3 fatty acid supplementation.
- Consumption of more than two servings of fish per week.
- Injured and unable to participate in regularly schedule conditioning or competitions.
- Acute concussion experienced within 30 days of starting the study.
- Fish allergies.
Data sourced from ClinicalTrials.gov (NCT04796207). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.