N/A
Completed N=12
Influence of Nocturnal Light Exposure on the Impairment of Glucose Tolerance Induced by Chronic Sleep Restriction
Glucose Intolerance · sleep deprivation · Sleep
Source: ClinicalTrials.gov NCT04868539 ↗
Enrolled (actual)
12
Serious AEs
0.0%
Results posted
Oct 2025
Primary outcomePrimary: Impairment of Insulin Sensitivity — -0.80; 0.55 (mU/L)^-1 min^-1
Summary
This project is designed to test for the first time whether glucose metabolism is differentially impaired by sleep restriction with and without additional exposure to artificial light at night (ALAN).
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Impairment of Insulin Sensitivity |
-0.80; 0.55 | — |
| PRIMARY Impairment of Glucose Tolerance |
524.4; 179.1 | — |
| PRIMARY Duration of Nocturnal Melatonin Secretion |
432.9; 579.6 | — |
| SECONDARY Acute Insulin Response to Glucose |
-110.41; -37.04 | — |
| SECONDARY Glucose Effectiveness |
-0.00049; -0.0012 | — |
| SECONDARY Insulin Area-under-the-curve |
663.4; -71.6 | — |
| SECONDARY Duration of Endogenous Melatonin Secretory Profile |
581.7; 609.6 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy adults with conventional and regular sleep-wake timing
- Non-smokers
- Completion of medical, psychological, and sleep screening tests
- Able to spend 33 consecutive days/nights in the laboratory
- Normal color vision
Exclusion Criteria
- History of neurological or psychiatric disorder
- History of sleep disorder or regular use of sleep-promoting medication
- Current prescription, herbal, or over-the-counter medication use
- Traveling across 2 or more time zones within past 3 months
- Donating blood within past 8 weeks
- Worked night or rotating shift work within past 3 years
- Hearing impairment, visual impairment
- History of eye trauma or surgery
- Drug or alcohol dependency
Data sourced from ClinicalTrials.gov (NCT04868539). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.