N/A
Completed N=1,390
Assessing Testing Strategies for Safe Return to K-12 Schools in an Underserved Population
Source: ClinicalTrials.gov NCT04875520 ↗Enrolled (actual)
1,390
Serious AEs
—
Results posted
Jul 2025
Primary outcomePrimary: Overall Rate of All COVID-19 Cases in Schools. — 453; 297 Completed tests — p=0.25
Summary
The primary goal of this study is to determine the most effective SARS-CoV-2 testing strategy for successful return of in-person school in the under-served communities of St. Louis.
Regular screening testing has been recommended by the CDC as an additive mitigation strategy for in-person schools in areas of high community transmission. We will compare the effectiveness and acceptance of two different school-based testing strategies among students and school staff (symptomatic testing only versus weekly surveillance testing plus symptomatic testing), measuring school-based SARS-CoV-2 transmission through a cluster randomized trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Overall Rate of All COVID-19 Cases in Schools. |
453; 297 | 0.25 |
Eligibility Criteria
Inclusion Criteria
- A student or staff in one of the five school districts.
- Household members of a student or staff member in the five school districts.
Exclusion Criteria
- People not affiliated with the school.
Data sourced from ClinicalTrials.gov (NCT04875520). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.