Phase 2
N=10
A Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of Subjects With Plaque Psoriasis
Plaque Psoriasis
Bottom Line
View on ClinicalTrials.gov: NCT04908514 ↗Enrolled (actual)
10
Serious AEs
0.0%
Results posted
Mar 2025
Primary outcome: Primary: Change From Baseline in the Psoriasis Area and Severity Index (PASI) — -4.3; -7.6; -8.0 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- ADX-629 (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Aldeyra Therapeutics, Inc.
- Primary completion
- Jan 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change From Baseline in the Psoriasis Area and Severity Index (PASI) |
-4.3; -7.6; -8.0 | — |
| SECONDARY Number of Subjects With a ≥ 50% Reduction Change From Baseline for PASI Score |
3 | — |
| SECONDARY Number of Subjects With a ≥ 75% Reduction Change From Baseline for PASI Score |
2 | — |
| SECONDARY Change From Baseline in the Investigator's Global Assessment (IGA) |
-0.50; -0.68; -0.85 | — |
Summary
A Multi-Center, Open-Label, Phase 2 Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of ADX-629 Administered Orally to Subjects with Plaque Psoriasis
Eligibility Criteria
Inclusion Criteria
- Subject is a male or non-pregnant female 18 years of age or older.
- Subject has provided written informed consent.
- Females must be post-menopausal, surgically sterile, or use a highly effective method of birth control during the trial and for 30 days after the last administration of test article. Women of childbearing potential (WOCBP) must have a negative urine pregnancy test (UPT) at Visit 1/Screening and Visit 2/Baseline.
- Male subjects who are not surgically sterile (e.g., vasectomy performed at least 6 months prior to trial entry) and are sexually active with a female partner who is of childbearing potential must agree to use an effective form of birth control for the duration of the trial and for 90 days after completion of treatment.
- Subject, in the investigator's opinion, is in good general health and free of any disease state or physical condition that might impair evaluation of plaque psoriasis or exposes the subject to an unacceptable risk by trial participation.
Exclusion Criteria
- Subject is pregnant, lactating, or is planning to become pregnant during the trial.
- Subject has a physical condition which, in the investigator's opinion, might impair evaluation of plaque psoriasis or which exposes the subject to an unacceptable risk by trial participation.
- Subject is currently enrolled in an investigational drug, biologic, or device trial.
- Subject has used an investigational drug, investigational biologic, or investigational device treatment within 30 days prior to Visit 2/Baseline.
Data sourced from ClinicalTrials.gov (NCT04908514). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.