N/A
Completed N=125
Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia
Effects of Family History of Alcoholism and Sex on Alcohol Analgesia
Source: ClinicalTrials.gov NCT04925076 ↗
Enrolled (actual)
125
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcomePrimary: Heat Pain Threshold — 43.56; 43.63; 42.28; 43.94 degrees celsius — p=.92
Summary
Self-medication of pain with alcohol is a common, yet risky, behavior. Evidence suggests family history of alcoholism may affect the degree to which alcohol use relieves pain, but the independent contributions of expectation and conditioning have not been previously studied. Interactive effects of sex and family history are also currently unclear. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Heat Pain Threshold |
43.56; 43.63; 42.28; 43.94; 43.20; 43.43 | .92 |
| PRIMARY Heat Pain Tolerance |
48.33; 48.13; 46.65; 47.50; 48.18; 47.95 | .38 |
| PRIMARY Heat Pain Intensity Ratings |
25.58; 25.48; 24.51; 27.11; 28.41; 25.76 | .83 |
| PRIMARY Perceived Pain Relief |
33.44; 32.18; 35.64; 37.60; 13.63; 13.76 | .36 |
| PRIMARY Dorsolateral Prefrontal Cortex Activation |
-.01; -.02; .04; .097; .099; .019 | .66 |
| PRIMARY Hypothalamus Activation |
-.096; -.047; .007; -.036; -.083; .018 | .55 |
| PRIMARY Medial Prefrontal Cortex Activation |
-.173; -.163; -.096; -.173; -.183; -.201 | .34 |
| PRIMARY Nucleus Accumbens Activation |
-.037; .055; .075; .131; .091; .103 | .30 |
| PRIMARY Periaqueductal Gray Activation |
-.162; -.089; .055; .052; .012; -.038 | .29 |
| PRIMARY Anterior Cingulate Cortex Activation |
.020; .045; .082; .040; .049; .038 | .32 |
| PRIMARY Amgydala Activation |
-.155; -.039; .013; -.061; -.050; -.007 | .50 |
| PRIMARY Hippocampus Activation |
-.154; -.130; -.116; -.128; -.074; -.083 | .76 |
| PRIMARY Insula Activation |
.220; .286; .270; .318; .389; .298 | .44 |
| PRIMARY Postcentral Gyrus Activation |
-.139; -.038; -.068; -.041; -.053; -.085 | 0.45 |
| PRIMARY Thalamus Activation |
-.141; -.076; .023; -.022; -.033; -.027 | .57 |
Eligibility Criteria
Inclusion Criteria
- Consume at least 1 drink/month over the past 6 months
Exclusion Criteria
- History of chronic pain
- Current use of opioids
- Current major depression
- History of any psychotic disorder
- Undercontrolled hypertension or diabetes
- History of neurologic disease
- History of serious medical illness
- History of drug or alcohol dependence, including nicotine, or a pattern of hazardous alcohol use
- Safety concerns related to MRI (for example, implants or pacing devices)
Data sourced from ClinicalTrials.gov (NCT04925076). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.