N/A
Completed N=10
Circadian Rhythm Disruption Effects on Smoke Inhalation
Inflammation · sleep deprivation · Circadian Rhythm Sleep Disorder, Shift Work Type · Smoke Inhalation
Source: ClinicalTrials.gov NCT04955431 ↗
Enrolled (actual)
10
Serious AEs
0.0%
Results posted
May 2025
Primary outcomePrimary: Blood Inflammation — 0.69; 0.79; 2.33; 1.63 pg/mL — p=<0.05
Summary
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians. Persistent occupational exposure to particulate matter represents a unique hazard for firefighters, underpinning a burgeoning research area. This trial will evaluate the effects of sleep deprivation and circadian rhythm disruption on the inflammatory response to woodsmoke associated particulate matter exposure. Participants will undergo 2 experimental trials in a randomized cross-over design. Participants will have either an 8-hour sleep opportunity or a 4-hour sleep opportunity prior to reporting to lab for a 45 minute simulated firefighting trial (wood smoke associated particulate matter filtered to 2.5 um at a concentration of 250 ug/m^3, while exercising at a moderate intensity). The effects of sleep restriction and simulated firefighting will be measured.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Blood Inflammation |
0.69; 0.79; 2.33; 1.63 | <0.05 sig |
| SECONDARY Exhaled Breath Condensate Pentraxin-3 |
0.97; 0.95; 0.96; 0.96 | >0.05 |
Eligibility Criteria
Inclusion Criteria
- Healthy
- Male
- 18 - 44 years of age
Exclusion Criteria
- Preexisting cardiometabolic and/or pulmonary diseases
- Preexisting sleep disorder
- Smoking (current or within last year)
Data sourced from ClinicalTrials.gov (NCT04955431). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.