N/A
N=360
Alcohol Metabolism and Disease Risk in Asians
Healthy
Bottom Line
View on ClinicalTrials.gov: NCT04967599 ↗Enrolled (actual)
360
Serious AEs
—
Results posted
Dec 2024
Primary outcome: Primary: Peak Number of Alcohol Drinks Consumed in a Day — 3.7; 4.2; 3.4; 3.0 drinks — p=.81
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Phenotype Feedback Intervention (Behavioral); Genotype Feedback Intervention (Behavioral)
- Age
- Pediatric, Adult · 17+ yrs
- Sex
- All
- Sponsor
- University of Southern California
- Primary completion
- Jan 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Peak Number of Alcohol Drinks Consumed in a Day |
3.7; 4.2; 3.4; 3.0; 2.8; 3.2 | .81 |
| SECONDARY Number of Drinking Days |
2.4; 2.3; 2.3; 2.3; 2.0; 2.2 | .46 |
| SECONDARY Number of Alcoholic Drinks Consumed on Weekend |
2.7; 3.1; 2.7; 2.1; 1.9; 2.7 | .49 |
| SECONDARY Number of Alcoholic Drinks Consumed Weekly |
3.2; 4.0; 2.9; 2.8; 2.2; 2.7 | .59 |
| SECONDARY Number of Participants Identified as Non-drinkers |
14; 15; 16; 4; 9; 4 | .29 |
| SECONDARY Alcohol Flush Cure Use Rate |
7; 6; 3; 97; 91; 94 | .49 |
Summary
The primary pathway of alcohol metabolism involves two main enzymes, alcohol and aldehyde dehydrogenase. Several genes that encode these enzymes have variants that alter the rate of alcohol metabolism and increase levels of acetaldehyde. The variant ALDH2*2 allele is associated with the flushing response (i.e., Asian glow) and is found almost exclusively in individuals of east Asian descent. Although having variant ALDH2 alleles is protective against heavy drinking and alcohol use disorders, for those who do drink, these variants also are associated with elevations in risk for several health problems. The premise of this study is that we can affect early drinking behavior through personalized communication about these health-related risks.
Eligibility Criteria
Inclusion Criteria
- All participants will be of Asian heritage (i.e. Chinese/Taiwanese, Japanese, Korean, Vietnamese).
- About half of the sample will be incoming first-year undergraduates
- About half of the sample will be current undergraduates who self-report having flushed when they first started drinking alcohol
Data sourced from ClinicalTrials.gov (NCT04967599). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.