Phase 1
N=34
Clinical Effect, Safety and Tolerability of GSK1070806 in Atopic Dermatitis
Dermatitis, Atopic
Bottom Line
View on ClinicalTrials.gov: NCT04975438 ↗Enrolled (actual)
34
Serious AEs
0.0%
Results posted
Jul 2024
Primary outcome: Primary: Percent Change From Baseline (PCFB) in Eczema Area and Severity Index (EASI) Score at Week 12 in Group 1 — -66.11; -32.81 Percent Change
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- GSK1070806 (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- GlaxoSmithKline
- Primary completion
- Dec 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Percent Change From Baseline (PCFB) in Eczema Area and Severity Index (EASI) Score at Week 12 in Group 1 |
-66.11; -32.81 | — |
| SECONDARY Change From Baseline in EASI Score at Week 12 in Group 1 |
-16.83; -7.15 | — |
| SECONDARY Number of Participants Achieving EASI-50, ≥ 50% Reduction in EASI Score at Week 12 in Group 1 |
14; 3; 5; 6 | — |
| SECONDARY Number of Participants Achieving EASI-75, ≥ 75% Reduction in EASI Score at Week 12 in Group 1 |
7; 1; 12; 8 | — |
| SECONDARY Number of Participants Achieving EASI-90, ≥ 90% Reduction in EASI Score at Week 12 in Group 1 |
5; 1; 14; 8 | — |
| SECONDARY Number of Participants With Investigator Global Assessment (IGA) Score of 0 or 1 at Week 12 in Group 1 |
4; 1; 1; 0 | — |
| SECONDARY Percent Change From Baseline in EASI Score at Week 12 in Group 2 |
-94.213; -38.868 | — |
| SECONDARY Number of Participants With Adverse Events (AEs) and Serious Adverse Events (SAEs) - Groups 1 and 2 |
10; 6; 0; 0 | — |
| SECONDARY Number of Participants With Worst Case Vital Signs Results by Potential Clinical Importance (PCI) Criteria Post-Baseline Relative to Baseline - Groups 1 and 2 |
0; 0; 22; 10; 1; 1 | — |
| SECONDARY Number of Participants With Worst Case 12-lead Electrocardiogram (ECG) Post-Baseline Relative to Baseline - Groups 1 and 2 |
0; 0 | — |
| SECONDARY Number of Participants With Worst Case Urinalysis Results Post-Baseline Relative to Baseline - Groups 1 and 2 |
0; 0 | — |
| SECONDARY Number of Participants With Worst Case Chemistry Results by Potential Clinical Importance (PCI) Criteria Post-Baseline Relative to Baseline - Groups 1 and 2 |
0; 0; 22; 11; 1; 0 | — |
| SECONDARY Number of Participants With Worst Case Hematology Results by Potential Clinical Importance (PCI) Criteria Post-Baseline Relative to Baseline - Groups 1 and 2 |
0; 0; 22; 11; 1; 0 | — |
| SECONDARY Number of Participants With Anti-drug Antibodies (ADA)- Groups 1 and 2 |
0; 0 | — |
Summary
This study will evaluate efficacy and safety of GSK1070806 in moderate to severe atopic dermatitis (AtD) participants.
Eligibility Criteria
Inclusion criteria
- Moderate to severe AtD (confirmed by a dermatologist) according to the Hannifin and Rajka criteria or Eichenfield revised criteria.
- Onset of AtD symptoms occurring at least 6 months prior to Screening, with stable disease for at least 1 month prior to Screening.
- Eczema Activity Severity Index greater than or equal to (>=)16; Investigator Global Assessment score >=3.
- Group 1- Biologic Naïve: Topical First Line Treatment: Documented recent history (within 6 months before Screening) of: a) either an inadequate response (IR) to out-patient treatment with at least one topical treatment (intermittent topical corticosteroid, topical calcineurin inhibitor), topical inhibitors or Phosphodiesterase 4 inhibitor (Crisaborole); b) or that topical treatments were otherwise not recommended.
- Group 2- Dupilumab-Inadequate Responder: Documented history of an IR to dupilumab: a) either following at least 16 weeks of treatment according to the Investigator's judgement; b) or intolerant to dupilumab owing to adverse events.
Exclusion Criteria
- Other than AtD, the presence of a significant skin morbidity that will influence the Investigator's ability to assess the severity of the disease (e.g. psoriasis, confirmed or suspected cutaneous T-cell lymphoma, autoimmune bullous disease, fixed drug reaction and Stevens Johnson Syndrome).
- Participants with any uncontrolled medical conditions, other than AtD, that in the opinion of the investigator puts the participant at unacceptable risk or will likely interfere with study assessments or data integrity. Other medical conditions should be stable at the time of screening and be expected to remain stable for the duration of the study.
- Treatment with biologic agents (investigational and marketed monoclonal antibodies) within 12 weeks or 5 pharmacokinetic half-lives (whichever is longer) prior dosing on Day 1.
- Treatment with Janus Activated Kinase inhibitors (e.g. baricitinib, upadacitinib) within 4 weeks or 5 half-lives (whichever is longer) prior to dosing on Day 1.
- Mycophenolate mofetil, azathioprine, methotrexate, or calcineurin inhibitors within 4 weeks of Screening.
Data sourced from ClinicalTrials.gov (NCT04975438). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.