N/A
N=2,868
Increasing Vaccine Uptake Among Adolescents in the Rural South
Vaccine Hesitancy
Bottom Line
View on ClinicalTrials.gov: NCT04999267 ↗Enrolled (actual)
2,868
Serious AEs
—
Results posted
Dec 2024
Primary outcome: Primary: Difference in the Percentage of Adolescents Who Ever Received at Least One Dose of HPV Vaccination in the Intervention Group After the Intervention Implementation Compared With Before Intervention Implementation — 21.7 percentage of adolescents — p=<0.0001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- INVEST (Other)
- Age
- Pediatric, Adult, Older Adult
- Sex
- All
- Sponsor
- Duke University
- Primary completion
- Nov 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Difference in the Percentage of Adolescents Who Ever Received at Least One Dose of HPV Vaccination in the Intervention Group After the Intervention Implementation Compared With Before Intervention Implementation |
21.7 | <0.0001 sig |
| SECONDARY Difference in Percentage of Adolescents Who Have Completed the HPV Vaccination Series (2 Doses Depending on Age at Vaccination Initiation) in the Intervention Group After Implementation Compared With Before Intervention Implementation |
7.6 | <.0001 sig |
| SECONDARY Fidelity of Intervention Across Intervention Schools |
87.5 | — |
Summary
The benefits of adolescent vaccines are well known for preventing meningococcal infection and human papillomavirus (HPV)-related pre-cancerous lesions. Yet, many adolescents in the United States (US) remain under-vaccinated, with vaccination rates among rural adolescents significantly lower than among their urban peers. In addition, there are urban-rural disparities in the coverage of HPV vaccine, particularly in Southern states like North and South Carolina, which currently fall below the Healthy People 2020 goal of ≥80% coverage. The goal of the proposed study is to evaluate the feasibility and preliminary efficacy of a school-based intervention for increasing vaccine uptake among adolescents in rural North and South Carolina.
Eligibility Criteria
Inclusion Criteria
- Any public middle school in Cherokee County, South Carolina or Rockingham County, North Carolina school districts
Data sourced from ClinicalTrials.gov (NCT04999267). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.