N/A
N=62
Training in Ataxia - Individuals With Degenerative Cerebellar Diseases
Cerebellar Ataxia
Bottom Line
View on ClinicalTrials.gov: NCT05002218 ↗Enrolled (actual)
62
Serious AEs
4.8%
Results posted
Nov 2025
Primary outcome: Primary: Change in Assessment and Rating of Ataxia (SARA) Score — -2.4; -0.9; -1.5; -0.2 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Aerobic Training (Behavioral); Balance Training (Behavioral)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Columbia University
- Primary completion
- Nov 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Assessment and Rating of Ataxia (SARA) Score |
-2.4; -0.9; -1.5; -0.2; -1.4; 0 | — |
| SECONDARY Average Gait Speed |
0.90; 0.95; 0.80; 0.89; 0.80; 0.80 | — |
| SECONDARY Dynamic Gait Index Score |
11.8; 11.7; 12.8; 13.2; 13.0; 13.2 | — |
| SECONDARY Timed Up and Go (TUG) |
17.0; 16.6; 15.5; 15.7; 15.5; 15.7 | — |
| SECONDARY Fatigue Severity Scale (FSS) Score |
41.2; 33.5; 33.3; 35.0; 35.6; 34.8 | — |
| SECONDARY Quality of Life (QOL) - Physical Health |
55.8; 59.1; 54.3; 60.1; 57.1; 59.8 | — |
| SECONDARY Quality of Life (QOL) - Psychological |
65.6; 68.1; 63.1; 67.6; 68.8; 67.0 | — |
| SECONDARY Quality of Life (QOL) - Social Relationships |
60.1; 64.8; 65.5; 53.0; 64.2; 60.1 | — |
| SECONDARY Quality of Life (QOL) - Environment |
65.5; 68.3; 70.5; 66.1; 69.5; 69.6 | — |
| SECONDARY Prevalence of Desired Changes in Diffuse Tensor Imaging |
— | — |
| SECONDARY Prevalence of Cerebellar Volume |
— | — |
| SECONDARY Prevalence of Desired Changes in Resting State fMRI Scans |
— | — |
Summary
Balance and aerobic training show promise as treatments for degenerative cerebellar diseases, but the neural effects of both training methods are unknown. The goal of this project is to evaluate how each training method impacts the brain, and particularly, the degenerating cerebellum. Various neuroimaging techniques will be used to accomplish this goal and test the hypothesis that balance training impacts brain structures outside the cerebellum whereas aerobic training causes more neuroplastic changes within the cerebellum.
Eligibility Criteria
Inclusion Criteria
- Diagnosed with spinocerebellar ataxia
- Cerebellar atrophy on MRI
- Prevalence of ataxia on clinical exam
- Ability to safely ride a stationary exercise bike
Exclusion Criteria
- Other neurologic conditions
- Heart disease
- Cognitive impairment
- Medical instability
Data sourced from ClinicalTrials.gov (NCT05002218). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.