N/A
Completed N=88
Angiotensin II Pathway and Postoperative Hypoxemia
Source: ClinicalTrials.gov NCT05055570 ↗Enrolled (actual)
88
Serious AEs
0.0%
Results posted
Jan 2024
Primary outcomePrimary: The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia. — 100; 78.5 pg / mL
Summary
Acute type A aortic dissection is often accompanied by postoperative hypoxemia, the cause of which is not fully understood. Angiotensin II is an important component of the renin-angiotensin system (RAS), which has been suggested to be involved in the development of aortic dissection and pulmonary inflammation.The purpose of this study was to investigate the role and mechanism of angiotensin II pathway in postoperative hypoxemia after acute type A aortic dissection, and to provide reference for clinical application
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Difference Concentrations of ANG II in Serum Between Patients With and Without Postoperative Hypoxemia. |
100; 78.5 | — |
| SECONDARY The Risk Factors for Postoperative Hypoxemia in Stanford Type A Acute Aortic Dissection Patients. |
— | — |
| SECONDARY Duration of Stay in the Intensive Care Unit |
— | — |
Eligibility Criteria
Inclusion Criteria
- patients undergoing surgery for acute type A aortic dissection
- age between 18 to 80
Exclusion Criteria
- perioperative severe cardiac insufficiency
- rejection of consent
Data sourced from ClinicalTrials.gov (NCT05055570). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.