N/A
Completed N=38
Kidney Transplant Low-AGE Diet Study
Renal Transplant
Source: ClinicalTrials.gov NCT05104242 ↗
Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Dec 2024
Primary outcomePrimary: Skin Autofluorescence (SAF) Levels at 6 Months — 2.8; 2.8 Arbitrary units
Summary
The purpose of the present study is to test the feasibility of conducting a larger randomised controlled trial (RCT) which will investigate whether a diet low in toxins called advanced glycation end-products (AGEs) decreases skin autofluorescence (SAF; AGE accumulation in the skin) levels and improves heart and circulatory (i.e. cardiovascular) health in persons with a kidney transplant.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Skin Autofluorescence (SAF) Levels at 6 Months |
2.8; 2.8 | — |
| SECONDARY Participant Adherence to Diets |
17; 9 | — |
| SECONDARY Skin Autofluorescence (SAF) Trend. |
-0.22; -0.45 | — |
| SECONDARY Dietary AGE Intake at 6 Months |
20447; 5515 | — |
Eligibility Criteria
Inclusion Criteria
- Adults (>18 years) with a functioning (not on dialysis) kidney transplant.
- More than 12 months post-transplant.
- Able and willing to give informed consent.
- Skin Autofluorescence levels above the general population mean value for age.
Exclusion Criteria
- Persons with dark skin colour (i.e. Fitzpatrick skin colour type 5-6).
- Persons with malnutrition (Subjective Global Assessment [SGA] score <5).
- Pregnancy or breast feeding or intending pregnancy.
- Active infection.
- Active rejection.
- Persons with learning difficulties.
- Prisoners.
Data sourced from ClinicalTrials.gov (NCT05104242). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.