N/A
Completed N=23
Investigation of Low-intensity Focused Ultrasound Parameters
Development of LIFU for Clinical Purposes
Source: ClinicalTrials.gov NCT05134233 ↗
Enrolled (actual)
23
Serious AEs
0.0%
Results posted
Jan 2025
Primary outcomePrimary: Waveforms — 1.06; 1.10; 0.97; 0.99 percentage of baseline MEP mV
Summary
This project examines the effects of different brain stimulation settings on muscle contractions. The investigators believe this study will help to better understand noninvasive brain stimulation techniques that may have the potential to aid in addiction, pain, and mental health issues. Participants undergo structural imaging, an fMRI and CT. These images are used to align the low-intensity focused ultrasound (LIFU) and transcranial magnetic stimulation (TMS) devices to temporarily change brain activity. Electromyography (EMG) will be used to record muscle contractions on the hand.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Waveforms |
1.06; 1.10; 0.97; 0.99; 1.03; 0.80 | — |
Eligibility Criteria
Inclusion Criteria
- Above criteria and must understand and speak English.
Exclusion Criteria
- Contraindications to MRI, CT, or TMS
- Claustrophobia
- Pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
- Pregnancy
- Active medical disorder or treatment with potential CNS effects
- History of neurologic disorder
- History of head injury resulting in loss of consciousness for >10 minutes
- History of alcohol or drug dependence
- Failure to provide a social security number or tax ID number. This is required for tax purposes or payment cannot be processed.
Data sourced from ClinicalTrials.gov (NCT05134233). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.