N/A
N=60
Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type
Cigarette Smoking · Nicotine Vaping
Bottom Line
View on ClinicalTrials.gov: NCT05177848 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Sep 2024
Primary outcome: Primary: Nicotine/Tobacco Products Substitution — 12.11; 4.82; 25.28; 17.08 mg of nicotine purchased — p=0.9793
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- All nicotine/ tobacco products at market price (Other); Nicotine vaping products at 1/2 market price (Other); Nicotine vaping products at 2x market price (Other); Heated tobacco products at 1/2 market price. (Other); Heated tobacco products at 2x market price. (Other); Nicotine pouch products at 1/2 market price. (Other); Nicotine pouch products at 2x market price. (Other)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Virginia Polytechnic Institute and State University
- Primary completion
- Jun 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Nicotine/Tobacco Products Substitution |
12.11; 4.82; 25.28; 17.08; 19.70; 10.73 | 0.9793 |
| PRIMARY Cigarette Demand |
212.39; 193.58; 221.66; 163.28; 186.03; 231.96 | 0.29 |
Summary
This study will investigate the relative appeal (abuse liability) of novel tobacco products, how the appeal is modulated by relative price, user type, and how novel products may substitute for one another.
Eligibility Criteria
Inclusion Criteria
- Provide informed consent
- Be at least 21 years of age or older
- Provide a breath sample for measuring carbon monoxide (CO ≥ 8 ppm)
- Stable tobacco use patterns for at least three months
- Be willing to sample NVPs, HTPs, and NPPs
- For exclusive cigarette smokers: smoke at least 10 cigarettes daily and do not use NVPs regularly (no more than 9 times in the last month)
- For dual cigarette/NVP users: smoke at least 5 cigarettes daily and use NVPs for at least 3 times in a week (report use of closed nicotine salt system)
Exclusion Criteria
- Have plans to move out of the area
- Have a serious or unstable physical or mental health condition
- Taking a tobacco cessation medication or medication that interferes with nicotine metabolism, motivation or reinforcement
- Report concrete, immediate plans to alter/quit using their usual nicotine products at the beginning of the study
Data sourced from ClinicalTrials.gov (NCT05177848). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.