N/A
N=39
Theta Connectivity in Working Memory
Executive Function
Bottom Line
View on ClinicalTrials.gov: NCT05204381 ↗Enrolled (actual)
39
Serious AEs
0.0%
Results posted
Nov 2025
Primary outcome: Primary: Number of Remembered Items — 1.72; 1.68; 1.68; 1.65 remembered items — p=0.783
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Theta-frequency near-zero phase lag stimulation (Device); Theta-frequency anti-synchrony stimulation (Device); Arrhythmic near-zero phase lag stimulation (Device); Arrhythmic independent stimulation (Device); Alpha-frequency near-zero phase lag stimulation (Device); Alpha-frequency anti-synchrony stimulation (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of North Carolina, Chapel Hill
- Primary completion
- Dec 2024
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Remembered Items |
1.72; 1.68; 1.68; 1.65; 1.71; 1.72 | 0.783 |
| PRIMARY Strength of Functional Connectivity Between Frontal and Parietal Cortex in Theta-frequency |
0.143; 0.167; 0.116; 0.086; 0.149; 0.156 | 0.965 |
| SECONDARY Average Phase Lag of Functional Connectivity Between Frontal and Parietal Cortex in Theta-frequency |
182.2; 177.4; 182.2; 181.2; 183.1; 183.1 | 0.089 |
Summary
The participants will perform a cognitive control task. During the task, rhythmic trains of transcranial magnetic stimulation will be delivered to the prefrontal cortex and parietal cortex. Participants will be screened for their ability to perform the task. Magnetic resonance imaging will be used to localize regions of interest to be targeted. Electroencephalography will be collected concurrent with stimulation.
Eligibility Criteria
Inclusion Criteria
- Between the ages of 18 and 35
- Right-handed
- Able to provide informed consent
- Have normal to corrected vision without color blindness
- Willing to comply with all study procedures and be available for the duration of the study Speak and understand English
- Participants will be invited back to the second session only if they are able to perform the task. The criteria for demonstrating the cognitive process of interest is that participants must show a benefit to their working memory percent correct during trials with an informative retro-cue relative to trials with an uninformative neutral cue
Exclusion Criteria
- Attention Deficit Hyperactivity Disorder (ADHD) (currently under treatment)
- Neurological disorders and conditions, including, but not limited to:
- History of epilepsy
- Seizures (except childhood febrile seizures) Dementia
- History of stroke
- Parkinson's disease
- Multiple sclerosis
- Cerebral aneurysm
- Brain tumors
- Medical or neurological illness or treatment for a medical disorder that could interfere with study participation (e.g., unstable cardiac disease, HIV/AIDS, malignancy, liver or renal impairment)
- Prior brain surgery
- Any brain devices/implants, including cochlear implants and aneurysm clips
- History of current traumatic brain injury
- Failure to pass a colorblindness test
- (For females) Pregnancy or breast feeding
- Anything that, in the opinion of the investigator, would place the participant at increased risk or preclude the participant's full compliance with or completion of the study
Data sourced from ClinicalTrials.gov (NCT05204381). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.