N/A
Completed N=65
Effects of Daily Supplementation of 5-HTP on Body Composition
Source: ClinicalTrials.gov NCT05216406 ↗Enrolled (actual)
65
Serious AEs
0.0%
Results posted
Feb 2024
Primary outcomePrimary: Body Composition — 14.6; 12.6; 58.4; 57.7 Kilograms
Summary
The purpose of this investigation was to compare supplementation with 5-HTP to placebo on indices of body composition. A randomized trial compared a sample of 48 resistance-trained individuals taking either 100 mg of 5-hydroxytryptophan supplementation or a placebo.
The investigators tested anthropometric measurements using a multi-frequency bioelectrical impedance device (InBody® 270). The primary outcome (i.e., changes in anthropometric measurements) was assessed at the first visit (pre-test-) and post-test (8 weeks). Secondary outcomes include resting heart rate, blood pressure, and dietary intake.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Body Composition |
14.6; 12.6; 58.4; 57.7; 73; 70.2 | — |
| SECONDARY Dietary Habits |
1810; 1966; 576; 684; 796; 816 | — |
| SECONDARY Blood Pressure |
119; 117; 70; 67 | — |
| SECONDARY Resting Heart Rate |
70; 65 | — |
Eligibility Criteria
Inclusion Criteria
- Healthy or free of disease
- Minimum of 1 year of regular physical activity. Regular physical activity is defined by a minimum of 150 minutes of aerobic activity or performing muscle-strengthening exercises at least 2 days a week.
Exclusion Criteria
- Physically inactive
- Regularly used sleep aids of any kind
- Currently taking selective serotonin reuptake inhibitors (SSRIs) and/or 5-HTP containing supplements.
Data sourced from ClinicalTrials.gov (NCT05216406). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.