N/A
N=1,420
DirEct Versus VIdeo LaryngosCopE Trial
Acute Respiratory Failure
Bottom Line
View on ClinicalTrials.gov: NCT05239195 ↗Enrolled (actual)
1,420
Serious AEs
0.0%
Results posted
Aug 2024
Primary outcome: Primary: Number of Intubations With Successful Intubation on the First Attempt — 600; 504 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Video Laryngoscope (Other); Direct Laryngoscope (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University Medical Center
- Primary completion
- Nov 2022
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Intubations With Successful Intubation on the First Attempt |
600; 504 | — |
| SECONDARY Number of Participants With Severe Complications of Tracheal Intubation |
151; 149 | — |
Summary
Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States. Failure to intubate the trachea on the first attempt occurs in more than 10% of all tracheal intubation procedures performed in the emergency department (ED) and intensive care unit (ICU). Improving clinicians rate of intubation on the first attempt could reduce the risk of serious procedural complications.
In current clinical practice, two classes of laryngoscopes are commonly used to help clinicians view the larynx while intubating the trachea: a video laryngoscope (equipped with a camera and a video screen) and a direct laryngoscope (not equipped with a camera or video screen). For nearly all laryngoscopy and intubation procedures performed in current clinical practice, clinicians use either a video or a direct laryngoscope. Prior research has shown that use of a video laryngoscope improves the operator's view of the larynx compared to a direct laryngoscope. Whether use of a video laryngoscope increases the likelihood of successful intubation on the first attempt remains uncertain. A better understanding of the comparative effectiveness of these two common, standard-of-care approaches to laryngoscopy and intubation could improve the care clinicians deliver and patient outcomes.
Eligibility Criteria
Inclusion Criteria
- Patient is located in a participating unit.
- Planned procedure is orotracheal intubation using a laryngoscope.
- Planned operator is a clinician expected to routinely perform tracheal intubation in the participating unit.
Exclusion Criteria
- Patient is known to be less than 18 years old.
- Patient is known to be pregnant.
- Patient is known to be a prisoner.
- Immediate need for tracheal intubation precludes safe performance of study procedures.
- Operator has determined that use of a video laryngoscope or use of a direct laryngoscope is required or contraindicated for the optimal care of the patient.
Data sourced from ClinicalTrials.gov (NCT05239195). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.