N/A
N=40
Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease
Periodontal Diseases
Bottom Line
View on ClinicalTrials.gov: NCT05252000 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcome: Primary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- mechanical debridement (Device); adjunctive aPDT (Device); sham aPDT (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- The University of Texas Health Science Center, Houston
- Primary completion
- Oct 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Number of Bleeding Sites (Bleeding On Probing) |
-1.40; -1.80 | — |
| PRIMARY Change in Number of Bleeding Sites (Bleeding On Probing) |
-1.40; -1.80 | — |
| PRIMARY Change in Probing Depth (Periodontal Pocket Depth ) |
-0.03; -0.60 | — |
| PRIMARY Change in Probing Depth (Periodontal Pocket Depth ) |
-0.03; -0.60 | — |
| SECONDARY Microbiologic Profile of Plaque as Indicated by Percent of Total Abundance of 4 Oral Bacterial Complexes |
2.52; 2.98; 13.62; 12.00; 1.81; 2.21 | — |
| SECONDARY Microbiologic Profile of Plaque as Indicated by Percent of Total Abundance of 4 Oral Bacterial Complexes |
2.52; 2.98; 13.62; 12.00; 1.81; 2.21 | — |
| SECONDARY Microbiologic Profile of Plaque as Indicated by Percent of Total Abundance of 4 Oral Bacterial Complexes |
2.52; 2.98; 13.62; 12.00; 1.81; 2.21 | — |
| SECONDARY Change in Microbiologic Profile of Gingival Crevicular Fluid(GCF) |
— | — |
Summary
The purpose of this study is to compare clinical outcomes after mechanical debridement of at sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after treatment with or without aPDT
Eligibility Criteria
Inclusion Criteria
- One pocket on each side of the mouth (split design)
- Single rooted tooth
- Pocket depths measured greater than 4mm with bleeding on probing
- Horizontal bone loss
- No furcation involvement
Exclusion Criteria
- current heavy smokers (>10 cigarettes/day)
- have uncontrolled diabetes (HbA1c ≥ 6.5%)
- other uncontrolled systemic diseases that may comprise healing, such as Vitamin C deficiency, any neutrophil deficiencies, immunodeficiency syndromes, or leukemia
- taking antibiotics within 3 months before the procedure
- vertical bone defects that requires surgical regenerative treatment.
- Pregnancy
Data sourced from ClinicalTrials.gov (NCT05252000). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.