N/A Completed N=40 Randomized Single-blind Treatment

Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and Surgical Treatment of Teeth With Periodontal Disease

Periodontal diseases

Source: ClinicalTrials.gov NCT05252000 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Mar 2026

Primary outcomePrimary: Change in Number of Bleeding Sites (Bleeding On Probing) — -1.60; -1.40 bleeding sites

Summary

The purpose of this study is to compare clinical outcomes after mechanical debridement of at sites exhibiting plaque induced inflammation with or without adjunctive Antimicrobial photodynamic therapy (aPDT) and to assess the the microbiologic profile before and after treatment with or without aPDT

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Number of Bleeding Sites (Bleeding On Probing)	-1.40; -1.80	—
PRIMARY Change in Probing Depth (Periodontal Pocket Depth )	-0.03; -0.60	—
SECONDARY Microbiologic Profile of Plaque as Indicated by Percent of Total Abundance of 4 Oral Bacterial Complexes	2.52; 2.98; 13.62; 12.00; 1.81; 2.21	—
SECONDARY Change in Microbiologic Profile of Gingival Crevicular Fluid(GCF)	—	—

Eligibility Criteria

Inclusion Criteria

One pocket on each side of the mouth (split design)
Single rooted tooth
Pocket depths measured greater than 4mm with bleeding on probing
Horizontal bone loss
No furcation involvement

Exclusion Criteria

current heavy smokers (>10 cigarettes/day)
have uncontrolled diabetes (HbA1c ≥ 6.5%)
other uncontrolled systemic diseases that may comprise healing, such as Vitamin C deficiency, any neutrophil deficiencies, immunodeficiency syndromes, or leukemia
taking antibiotics within 3 months before the procedure
vertical bone defects that requires surgical regenerative treatment.
Pregnancy

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05252000). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.