N/A
N=31
Water Content in E-Liquids
Nicotine E-Cigarette Use
Bottom Line
View on ClinicalTrials.gov: NCT05257109 ↗Enrolled (actual)
31
Serious AEs
0.0%
Results posted
Oct 2024
Primary outcome: Primary: Irritation/Harshness — 1.04; 1.07; 1.03; 1.01 units on a scale — p=0.0014
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Water Concentration 1 (Other); Water Concentration 2 (Other); Water Concentration 3 (Other); Water Concentration 4 (Other)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Yale University
- Primary completion
- Mar 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Irritation/Harshness |
1.04; 1.07; 1.03; 1.01 | 0.0014 sig |
| PRIMARY Appeal Assessed Using the Labeled Hedonic Scale (LHS) Ranging From -100 to 100 |
9.91; 10.41; 7.1; 3.87 | <.05 sig |
| PRIMARY Appeal Assessed Using the Drug Effects Questionnaire (DEQ) |
48.99; 47.94; 45.94; 42.97 | <.05 sig |
Summary
This study looks at the effect of manipulating the water concentration of certain e-liquids on sensory perception.
Eligibility Criteria
Inclusion Criteria
- at least 21 years old
- able to read/write
- >/= 6 mths e-cig use
- regular e-cig use (>/= 4 days/week)
- use of flavored e-cigs
- use of nicotine containing e-cigs
- urine cotinine >/= 200ng/ml
- no plan to quit e-cig use
Exclusion Criteria
- breastfeeding, pregnant, trying to become pregnant
- Medical conditions that increase risk of respiratory problems among participants
- Current use of illegal substances
- Medical conditions increasing risk of respiratory problems in nonpatient populations
- Current diagnosis of an untreated psychiatric condition
- Not fully vaccinated for Coronavirus-19
Data sourced from ClinicalTrials.gov (NCT05257109). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.