N/A N=131

ATP Level and Cough Sensitivity to ATP in Subjects With Refractory/Unexplained Chronic Cough

Refractory/Unexplained Chronic Cough

Bottom Line

View on ClinicalTrials.gov: NCT05265871 ↗

Enrolled (actual)

131

Serious AEs

—

Results posted

May 2025

Primary outcome: Primary: ATP Level in Sputum Supernatant — 2313.4; 1804.6 pM

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Kefang Lai
Primary completion: Jan 2024

Outcome Measures

Outcome	Result	p-value
PRIMARY ATP Level in Sputum Supernatant	2313.4; 1804.6	—
SECONDARY ATP Cough Sensitivity	3.16; 316	—

Summary

This is a cross-sectional study to investigate ATP level in induced sputum and cough sensitivity to ATP in subjects with refractory/unexplained chronic cough. 60 patients with refractory/unexplained chronic cough and 30 matched healthy controls were recruited. Demographic data, clinical characteristic, cough sacles and medical history records were collected. Cough chanllage(ATP and capsaicin) and ATP measurement in sputum were conducted.The difference of sputum ATP level between patients and control and the correlation between sputum ATP level and cough sensitivity to ATP were analyzed.

Eligibility Criteria

Inclusion criteria for patients:

≥18 years old
cough as sole symptom lasting ≥6 months
cough visual analogue score ≥30mm
diagnosed as RCC/UCC according to guidelines

Exclusion criteria for patients:

smoking currently or in the past 6 months, or a smoking history of >20 pack-year
a forced expiratory volume in 1 second/forced vital capacity ratio 20 pack-year
a forced expiratory volume in 1 second/forced vital capacity ratio <70%
a history of acute respiratory infection in the past 4 weeks
posstive findings of chest radiography
a history of chronic respiratory disease and allergic disease
any signs of cough hypersensitivity

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05265871). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.