N/A
Completed N=27
Carbon Dioxide (CO2) and Cognitive Impairment
Healthy
Source: ClinicalTrials.gov NCT05292378 ↗
Enrolled (actual)
27
Serious AEs
0.0%
Results posted
Mar 2026
Primary outcomePrimary: Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Basal Oxygen Consumption (OCR) — 18.74; 19.54 pmol/min
Summary
The purpose of the study is to better understand the biological mechanisms of carbon dioxide (CO2)-induced cognitive impairments.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Basal Oxygen Consumption (OCR) |
18.74; 19.54 | — |
| PRIMARY Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Total Stimulated Oxygen Consumption. |
6.91; 8.95 | — |
| PRIMARY Change in PMN (Polymorphonuclear Leukocyte) Activation as Measured by Time to Peak (TTP) Oxygen Consumption |
84.48; 67.77 | — |
Eligibility Criteria
Inclusion Criteria
- History of COVID-19 vaccination
- Weigh at least 110 pounds
Exclusion Criteria
- Colorblindness
- Inability to hear verbal instructions
- Cardiovascular disease, including a history of stroke
- Diabetes requiring the use of insulin
- Pregnancy
- Current asthma (an asthma attack within the past five years)
- Medications for or history of anxiety disorder diagnosis or panic attacks
- Medications which may affect cognition such as beta-blockers and CNS depressants
Temporary Exclusion Criteria
- Respiratory symptoms in the previous four weeks
- Use of sedating cold/allergy medications in the previous week
- Use of marijuana in the previous week
- Consumption of alcohol in the previous 24 hours
Additional Exclusion Criteria for Subjects undergoing the fMRI scan:
- History of head trauma or neurosurgery or neurological disorder
- Ferrous metal implanted in or on the body, electrical devices such as a pacemaker, nonremovable ferrous jewelry
- Surgical pins or plates above the neck
- History of eye injury involving metallic materials, shavings in eyes, or welding without a face mask
- Lead or iron tatoos
- Claustrophobia
- Back problems that would prevent the subject from laying still comfortably for up to 90 minutes
Additional Exclusion Criteria for Subjects undergoing CAIM
- Current or recent contact lens use
Data sourced from ClinicalTrials.gov (NCT05292378). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.