Phase 4
N=103
Bacteriostatic Saline as a Local Anesthetic in Minor Eyelid Procedures
Eyelid Tumor · Eyelid Bump · Eyelid Deformity · Eyelid Abscess · Eyelid Boil
Bottom Line
View on ClinicalTrials.gov: NCT05294640 ↗Enrolled (actual)
103
Serious AEs
0.0%
Results posted
Jun 2025
Primary outcome: Primary: Pain on Injection — 2.8; 3.6 score on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- 0.9% Bacteriostatic Local Anesthetic Injection (Drug); 1% Lidocaine with 1:100,000 epinephrine Local Anesthetic Injection (Drug); Eyelid Lesion Removal (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of California, San Francisco
- Primary completion
- Feb 2023
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain on Injection |
2.8; 3.6 | — |
| PRIMARY Pain of Procedure |
4.9; 2.0 | — |
| SECONDARY Number of Lesions That Needed Additional Anesthesia to Complete Procedure |
33; 5 | — |
| SECONDARY Bleeding Level |
29; 33; 25; 16; 4; 0 | — |
Summary
The investigators aim to assess whether bacteriostatic saline provides the same level of anesthesia as traditional local anesthesia while reducing pain associated with medication infusion in minor eyelid procedures
Eligibility Criteria
Inclusion Criteria
- Age >=18 years old
- Undergoing clinic-based periocular procedure
Exclusion Criteria
- Any other topical, oral or intravenous sedating medications given alongside procedure
- Allergy to saline, lidocaine or epinephrine
- Unable to provide consent due to cognitive impairment
Data sourced from ClinicalTrials.gov (NCT05294640). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.