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N/A N=125

Self-Management and Resilience Trajectories in African American Adults With Hypertension

Hypertension · Self-Management · Quality of Life · Compliance, Medication · Compliance, Treatment

Enrolled (actual)
125
Serious AEs
0.0%
Results posted
Apr 2026
Primary outcome: Primary: Systolic Blood Pressure — 138.35; 135.56 mmHg — p=0.0050

Study Design & Population

Study type
Observational
Phase
N/A
Interventions
Age
Adult, Older Adult · 25+ yrs
Sex
All
Sponsor
Case Western Reserve University
Primary completion
Mar 2025

Outcome Measures

OutcomeResultp-value
PRIMARY
Systolic Blood Pressure
138.35; 135.56 0.0050 sig
PRIMARY
Diastolic Blood Pressure
79.97; 76.37 0.0065 sig
PRIMARY
PROMIS Global Health-10 [Health-related Quality of Life]
12.90; 12.78; 13.61; 13.49 0.0005 sig

Summary

Hypertension (HTN) rates have increased worldwide, but the most significant increase in the incidence of morbidity and mortality has been in African Americans (AA) (43% vs 27% for other U.S. population groups). Despite evidence of positive benefits from lifestyle modification (healthy diet, reduced sodium intake, increased physical activity, smoking cessation) and prescribed antihypertensive therapy (AHT) many AA with HTN do not adhere to their treatment regimens. Consistent, effective lifelong self-management is required to sustain optimal BP control and thus reduce morbidity and mortality. Self-managing HTN to a blood pressure (BP) <130/80 mm Hg presents challenges such as juggling multiple medications and health care providers, dealing with complex recommendations and treatment regimens, and coping with negative emotional states. Few studies have examined the biopsychosocial mechanisms that foster effective HTN self-management and resilience among AA living with HTN. Understanding the mechanisms that influence HTN self-management and resilience in AA holds the promise of new modifiable targets for behavior-change interventions. This study explores the relationship among resilience precursors on hypertension (HTN) self-management behaviors, stress response, and the effects that these relationships have on health outcomes-health-related quality of life (HRQOL) and blood pressure (BP) in African Americans (AA) with HTN over a 6-month period.

Eligibility Criteria

Inclusion Criteria

  • Self-identify as African American
  • 25 years of age or older
  • Diagnosed with hypertension and prescribed one antihypertensive medication
  • BP >130/80 mmHg
  • Have at least one additional chronic health conditions
  • Able to read/understand English

Exclusion Criteria

  • Unable to give informed consent or judged to have impaired cognitive ability or severe memory
  • Have experienced a major CVD event or procedure (e.g., myocardial infarction, stroke, heart surgery) within the past year
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05308914). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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