N/A N=56 Randomized Double-blind Treatment

The Effect of Acute Intermittent Hypoxia on Motor Learning

Incomplete Spinal Cord Injury

Bottom Line

View on ClinicalTrials.gov: NCT05341466 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

May 2025

Primary outcome: Primary: Change in Corticospinal Excitability — 0.528; 0.132 mV*percentage of RMT — p=0.0098

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Acute Intermittent Hypoxia (Other); SHAM Acute Intermittent Hypoxia (Other)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: University of Colorado, Boulder
Primary completion: Jan 2025

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Corticospinal Excitability	0.528; 0.132	0.0098 sig
PRIMARY Step Length Asymmetry	-0.052; -0.0478	0.744
PRIMARY Step Time Asymmetry	0.0781; 0.0681	0.269
PRIMARY Net Metabolic Power	3.87; 4.27	0.020 sig

Summary

The goal of this study is to examine the effect of repetitive acute intermittent hypoxia on motor learning abilities in able-bodied individuals for subsequent study in individuals with incomplete spinal cord injury.

Eligibility Criteria

Inclusion Criteria

18 to 70 years old (the latter to reduce likelihood of heart disease);
Medically stable with medical clearance from physician to participate;
Motor-incomplete spinal cord injuries at or below C2 and at or above L5;
AIS A-D at initial screen, or other non-traumatic spinal cord injury disorders (e.g. multiple sclerosis, ALS, tumors, acute transverse myelitis, etc.);
More than 1 year since iSCI to minimize confounds of spontaneous neurological recovery;
Ability to advance one step overground with or without assistive devices;

Exclusion Criteria

Severe concurrent illness or pain;
Recurrent autonomic dysreflexia;
History of cardiovascular/pulmonary complications;
Concurrent physical therapy;
Pregnant at time of enrollment or planning to become pregnant;
Untreated painful musculoskeletal dysfunction, fracture or pressure sore;
History of seizures or epilepsy;
Recurring headaches;
Concussion within the last six months;
Depression or manic disorders
Metal implants in the head, or pacemaker.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT05341466). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.